Evidence map›Paper›PMID 42796769›Full record

ArticlePathogens (Basel, Switzerland)2026

Expansion of Dengue Virus Serotype 3 Genetic Diversity and Changing Serotype Composition in Brazil.

James Siqueira Pereira, Isabela Carvalho Brcko, Gabriel Montenegro de Campos, Vinicius Carius de Souza, Igor Santana Ribeiro, Mariana Matos Rolle, Brenno Vinicius Martins Henrique, Felicidade Mota Pereira, Arabela Leal E Silva de Mello, Aline de Andrade Freund and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

James Siqueira PereiraCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.ORCID 0000-0003-1893-8956
Isabela Carvalho BrckoCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.ORCID 0000-0002-6036-520X
Gabriel Montenegro de CamposCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.
Vinicius Carius de SouzaCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.
Igor Santana RibeiroCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.
Mariana Matos RolleLaboratório Central de Saúde Pública do Distrito Federal (LACEN-DF), Brasília 70620-000, DF, Brazil.ORCID 0000-0002-3405-4168
Brenno Vinicius Martins HenriqueLaboratório Central de Saúde Pública do Distrito Federal (LACEN-DF), Brasília 70620-000, DF, Brazil.ORCID 0000-0001-9778-9033
Felicidade Mota PereiraLaboratório Central de Saúde Pública da Bahia (LACEN-BA), Salvador 41253-190, BA, Brazil.ORCID 0000-0002-6938-161X
Arabela Leal E Silva de MelloLaboratório Central de Saúde Pública da Bahia (LACEN-BA), Salvador 41253-190, BA, Brazil.
Aline de Andrade FreundLaboratório Central de Saúde Pública do Paraná (LACEN-PR), São José dos Pinhais 83060-500, PR, Brazil.
Juan Gabriel Carvalho de AraújoLaboratório Central de Saúde Pública do Paraná (LACEN-PR), São José dos Pinhais 83060-500, PR, Brazil.
Talita Émile Ribeiro AdelinoLaboratório Central de Saúde Pública de Minas Gerais (LACEN-MG), Fundação Ezequiel Dias, Instituto Otávio Magalhães, Belo Horizonte 30510-010, MG, Brazil.
Marta Lamounier Moura Vargas CorgozinhoLaboratório Central de Saúde Pública de Minas Gerais (LACEN-MG), Fundação Ezequiel Dias, Instituto Otávio Magalhães, Belo Horizonte 30510-010, MG, Brazil.
Valnete das Graças Dantas AndradeLaboratório Central de Saúde Pública do Pará (LACEN-PA), Belém 66090-000, PA, Brazil.
Gleissy Adriane Lima BorgesLaboratório Central de Saúde Pública do Pará (LACEN-PA), Belém 66090-000, PA, Brazil.
Stephanni Figueiredo da SilvaLaboratório Central de Saúde Pública do Mato Grosso (LACEN-MT), Cuiabá 78043-300, MT, Brazil.
Elaine Cristina de OliveiraLaboratório Central de Saúde Pública do Mato Grosso (LACEN-MT), Cuiabá 78043-300, MT, Brazil.
Glaucilene da Silva CostaLaboratório Central de Saúde Pública de Rondônia (LACEN-RO), Porto Velho 76820-800, RO, Brazil.
Cicileia Correia da SilvaLaboratório Central de Saúde Pública de Rondônia (LACEN-RO), Porto Velho 76820-800, RO, Brazil.
Mariana de Souza AraujoDepartamento Municipal de Saúde, Secretaria Municipal de Saúde, Prefeitura Municipal de São Paulo, Sao Paulo 01004-000, SP, Brazil.
Melissa PalmieriDepartamento Municipal de Saúde, Secretaria Municipal de Saúde, Prefeitura Municipal de São Paulo, Sao Paulo 01004-000, SP, Brazil.
Luiz Carlos Junior AlcantaraInstituto René Rachou, Fundação Oswaldo Cruz (Fiocruz), Belo Horizonte 30190-002, MG, Brazil.ORCID 0000-0002-6769-9931
Claudia Renata Dos Santos BarrosCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.
Tiago Souza SallesCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.ORCID 0000-0002-5822-1426
Svetoslav Nanev SlavovCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.ORCID 0000-0003-0805-6140
Sandra Coccuzzo SampaioCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.
Maria Carolina EliasCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.ORCID 0000-0002-0501-8280
Marta GiovanettiInstituto René Rachou, Fundação Oswaldo Cruz (Fiocruz), Belo Horizonte 30190-002, MG, Brazil.ORCID 0000-0002-5849-7326
Alex Ranieri Jeronimo LimaCentro de Vigilância Viral e Avaliação Sorológica (CeVIVAS), Instituto Butantan, Sao Paulo 05503-900, SP, Brazil.ORCID 0000-0002-5283-7502

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 306199/2018-1Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88887.240060/2025-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/11944-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/07688-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/08965-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/11919-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/11920-5
6 · The paper itself

Abstract

Brazil is the most hyperendemic country for dengue, with historically dominant circulation of DENV-1 and DENV-2. Bayesian phylodynamic analyses of 489 Brazilian DENV-3 genomes, including 84 newly generated sequences, reveal a recent and sustained increase in the effective population size of DENV-3 associated with the recent introduction and expansion of the 3III_B.3.2 lineage. This increase coincides with a sharp rise in the proportion of laboratory-confirmed dengue cases attributed to DENV-3 among records with available serotype information from 2024 onwards and a shift in serotype dynamics in 2025, suggesting a change in serotype distribution and a potential risk of renewed DENV-3 outbreaks, particularly in populations with limited prior exposure to this serotype.

Indexed as

DengueDengue VirusGenetic VariationSerogroupBrazilGenome, ViralHumansPhylogenydengue virusDENV-3phylodynamicserotype composition

Identifiers

PMID42796769
PMCPMC13609987

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.