Evidence map›Paper›PMID 42796755›Full record

ArticlePathogens (Basel, Switzerland)2026

Quantitative Contrast-Enhanced Ultrasound Characterization of Perilesional Perfusion and Its Association with CD34-Positive Cell Density in a Rat Model of Hepatic Alveolar Echinococcosis.

Huan Zhao, Ya Xu, Xinyao Li, Zhen Wang, Yuhang Cheng, Jingyu Wang, Changhui Qu, Dan Dong, Ting Ma, Jian Dong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Huan ZhaoDepartment of Ultrasound, First Affiliated Hospital of Shihezi University, Shihezi 832008, China.
Ya XuDepartment of Ultrasound, First Affiliated Hospital of Shihezi University, Shihezi 832008, China.
Xinyao LiDepartment of Ultrasound, First Affiliated Hospital of Shihezi University, Shihezi 832008, China.
Zhen WangDepartment of Ultrasound, First Affiliated Hospital of Shihezi University, Shihezi 832008, China.
Yuhang ChengDepartment of Ultrasound, First Affiliated Hospital of Shihezi University, Shihezi 832008, China.
Jingyu WangDepartment of Ultrasound, First Affiliated Hospital of Shihezi University, Shihezi 832008, China.
Changhui QuDepartment of Ultrasound, First Affiliated Hospital of Shihezi University, Shihezi 832008, China.
Dan DongSchool of Medicine, Shihezi University, Shihezi 832003, China.
Ting MaDepartment of Ultrasound, First Affiliated Hospital of Shihezi University, Shihezi 832008, China.
Jian DongDepartment of Ultrasound, First Affiliated Hospital of Shihezi University, Shihezi 832008, China.ORCID 0009-0000-8082-471X

Funding

Bingtuan Science and Technology Program 2024ZD018Bingtuan Science and Technology Program 2024ZD050
6 · The paper itself

Abstract

Hepatic alveolar echinococcosis (HAE) is characterized by infiltrative growth and remodeling of perilesional host tissue, including microvascular changes. We investigated whether quantitative contrast-enhanced ultrasound (CEUS) could characterize perilesional perfusion and its animal-level association with CD34-positive cell density in a standardized rat model. Twenty female Sprague Dawley rats underwent ultrasound-guided intrahepatic HAE modeling and CEUS 10 weeks later. Peak enhancement (PE), rise time (RT), time to peak (TTP), wash-in rate (WiR), wash-in perfusion index (WiPI), and wash-in area under the curve (WiAUC) were measured in the perilesional zone and reference liver parenchyma. CD34-positive cell density was quantified by digital pathology. The perilesional zone showed higher PE, WiR, WiPI, and WiAUC and shorter RT and TTP than the reference liver parenchyma (all FDR-adjusted

Indexed as

Antigens, CD34Contrast MediaEchinococcosis, HepaticLiverAnimalsCell CountDisease Models, AnimalFemaleRatsRats, Sprague-DawleyUltrasonographyAntigens, CD34Contrast MediaCD34-positive cell densitycontrast-enhanced ultrasoundhepatic alveolar echinococcosismicrovascular perfusionperilesional zonetime–intensity curve

Identifiers

PMID42796755
PMCPMC13610811

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.