Iron, Tuberculosis, and Particle-Related Exposures Including Smoking.

Andrew J Ghio, Edward R Pennington, Jairus C Pulczinski, Elizabeth D Hilborn, Stephen L Tilley

Abstract readReview

In one paragraph

Review in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew J GhioUS Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

Edward R PenningtonUS Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

Jairus C PulczinskiUS Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

Elizabeth D HilbornCollege of Public Health, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-3035-3101

Stephen L TilleyDivision of Pulmonary Diseases and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The availability of iron controls the abundance and diversity of life. Microbial pathways for iron acquisition account for their replication and virulence. The balance of interactions defining a microbial community can be altered by environmental stress. Decreased iron availability applies a selective pressure that results in increased competition for the metal. The complexation of the host metal by cigarette smoke and other particles induces a functional iron deficiency in the respiratory tract of the exposed individual.

Indexed as

IronMycobacterium tuberculosisParticulate MatterSmokingTuberculosisHumansIronParticulate Matterair pollutionironsilicon dioxidesmokingtuberculosis

Identifiers

PMID42796750

DOI10.3390/pathogens15090982

PMCPMC13610849

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.