Evidence map›Paper›PMID 42796619›Full record

ArticleMolecules (Basel, Switzerland)2026

Baicalein Attenuates Disuse-Driven Skeletal Senescence in Association with Gut Microbiota Modulation.

Xin Zhao, Tingting Ren, Wei Bai, Hong Wang, Siddiq Ur Rahman, Xiaoni Deng, Kang Ru, Genyang Zhang, Wenjuan Zhang, Airong Qian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xin ZhaoLaboratory for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Tingting RenLaboratory for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Wei BaiLaboratory for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Hong WangResearch Center for Toxicological and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an 710065, China.ORCID 0000-0002-1215-386X
Siddiq Ur RahmanDepartment of Computer Science and Bioinformatics, Khushal Khan Khattak University Karak, Karak 27200, Khyber Pakhtunkhwa, Pakistan.
Xiaoni DengLaboratory for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Kang RuLaboratory for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.ORCID 0009-0003-1488-6762
Genyang ZhangLaboratory for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Wenjuan ZhangLaboratory for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
Airong QianLaboratory for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Laboratory for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.ORCID 0000-0002-0740-9218

Funding

Guangdong Basic and Applied Basic Research Foundation 2025A1515012343Key Research and Development Project of Shaanxi Province 2022SF-295National Innovation Talent Promotion Program S202010699126National Innovation Talent Promotion Program S202110699538National Innovation Talent Promotion Program XN2021031National Natural Science Foundation of China 32371371National Natural Science Foundation of China 81901917
6 · The paper itself

Abstract

The progression of skeletal senescence under mechanical unloading conditions elevates fracture risk, emerging as a critical health challenge for the general population and astronauts during spaceflight. Nevertheless, current therapeutic strategies demonstrate persistent limitations in efficacy and safety, with unresolved challenges in long-term sustainability. Baicalein, a natural flavonoid compound, exhibits favorable anti-aging and anti-inflammatory effects, while its therapeutic potential and underlying mechanism in bone disorders remain unknown. In this study, a hind limb unloading (HLU) rat model was employed as a disuse simulation, after which the HLU rats received baicalein treatment by gavage at 30 mg·kg

Indexed as

AgingBone and BonesFlavanonesGastrointestinal MicrobiomeAnimalsBiomarkersBone DensityBone RemodelingHindlimb SuspensionMaleOsteogenesisRatsbaicaleinBiomarkersFlavanonesbaicaleingut microbiotainflammatory responsemechanical unloadingskeletal senescence

Identifiers

PMID42796619
PMCPMC13610051

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.