Oxindole Compounds Induce NRF2-ARE Antioxidant Pathway in MCF7 Cells and Reduce Inflammatory Response in RAW264.7 Cells.

Baskar Selvaraj, Qui Ngoc Sang Nguyen, Seong-Hee Ko, Ki-Yeon Yoo, Suk Woo Kang, Jae Wook Lee

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Baskar SelvarajCenter for Natural Product Efficacy Optimization, Gangneung Institute, Korea Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea.ORCID 0009-0009-7210-7089

Qui Ngoc Sang NguyenCenter for Natural Product Efficacy Optimization, Gangneung Institute, Korea Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea.ORCID 0009-0005-7976-1439

Seong-Hee KoDepartment of Pharmacology, College of Dentistry, Gangwon National University, Gangneung 25457, Republic of Korea.

Ki-Yeon YooDepartment of Anatomy, College of Dentistry, Gangwon National University, Gangneung 25457, Republic of Korea.

Suk Woo KangCenter for Natural Product Efficacy Optimization, Gangneung Institute, Korea Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea.ORCID 0000-0002-5678-6394

Jae Wook LeeCenter for Natural Product Efficacy Optimization, Gangneung Institute, Korea Institute of Science and Technology (KIST), Gangneung 25451, Republic of Korea.

Funding

Korea Institute of Science and Technology 26E0271, 2G13220

6 · The paper itself

Abstract

Using previously reported chemical structures and synthetic methods, we prepared a series of 19 oxindole derivatives and evaluated their ability to activate the NRF2-ARE signaling pathway and induce the expression of downstream antioxidant genes. All 19 compounds activated NRF2-ARE signaling. Among them, OIC3 and OIC15 were selected for further investigation based on their relatively low EC

Indexed as

Anti-Inflammatory AgentsAntioxidant Response ElementsAntioxidantsInflammationNF-E2-Related Factor 2OxindolesSignal TransductionAnimalsHeme Oxygenase-1HumansKelch-Like ECH-Associated Protein 1MacrophagesMiceMolecular Docking SimulationNAD(P)H Dehydrogenase (Quinone)Oxidative StressAnti-Inflammatory AgentsAntioxidantsHeme Oxygenase-1Kelch-Like ECH-Associated Protein 1NAD(P)H Dehydrogenase (Quinone)NFE2L2 protein, humanNF-E2-Related Factor 2Oxindolesanti-inflammatory activityantioxidant activityEAW264.7 macrophagesKWAP1NQO1NRF2–ARE signaling pathwayoxidative stressoxindole compoundsPH-1

Identifiers

PMID42796597

DOI10.3390/molecules31183314

PMCPMC13609623

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.