ArticleMolecules (Basel, Switzerland)2026
Chronic Chrysin, but Not Diazepam, Induces Anxiolytic-like Effects Without Behavioral Tolerance.
Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundChrysin (5-7-dihydroxyflavone) exerts anxiolytic-like effects via the GABA
methodsThirty-five male Wistar rats were divided into five groups: vehicle, chrysin (1, 2.5, or 5 mg/kg), and diazepam (2 mg/kg, pharmacological control). Treatments were injected intraperitoneally for 32 days. On day 28, rats were evaluated in the elevated plus maze and locomotor activity tests. On day 32, all groups received a pharmacological challenge with 5 mg/kg diazepam and were assessed via sedative scale and the rota-rod test.
resultsChronic Chrysin (5 mg/kg) but not diazepam, maintained anxiolytic-like effects. No doses of chrysin showed pharmacological cross-tolerance to 5 mg/kg of diazepam, which produced incoordination and sedation, similar to vehicle.
conclusionsChronic treatment with chrysin (5 mg/kg) maintained their anxiolytic-like effects without pharmacological tolerance or cross-tolerance, unlike diazepam. This result supports the potential anxiolytic-like effects of chrysin in the long-term, as an alternative for anxiety disorders that require chronic treatment. This could contribute to the translational studies that could be applied to humans in the future.
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