ArticleMicromachines2026
Direct Molding of Luer Connections in PDMS Microfluidic Devices: Comparison with Conventional Interface Methods.
Article in Micromachines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Reliable world-to-chip connections remain a critical challenge in PDMS-based microfluidic devices, particularly under high-pressure flow conditions. In this work, we present a simple, low-cost, and reproducible method to directly mold male Luer cone fittings into PDMS devices during fabrication, without compromising the geometry of microchannels. To evaluate the effectiveness of this approach, we compared the performance of three connection types-PTFE tubing, metal pipes, and molded Luer adaptors-by measuring the infusion pressure at which fluid leakage occurred. Devices with integrated Luer adaptors consistently withstood higher pressures (up to 1555 mbar) with reduced variability across repeated connection cycles, while PTFE and metal connections failed at lower pressures and showed inconsistent leakage behavior. As a biological proof of concept,
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