Evidence map›Paper›PMID 42796198›Full record

ReviewMicromachines2026

Recent Developments, Applications, and Future Prospects of Advanced Hearts-on-a-Chip.

Aerin Kang, Hayun Lee, Gurnho Park, Taehong Kim, Hyoju Kim, Timothy Park, Sydney Staley, Miriam Kang, Youngbok Abraham Kang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Micromachines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aerin KangDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, 414 N. Meridian Street, #6088, Newberg, OR 97132, USA.
Hayun LeeDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, 414 N. Meridian Street, #6088, Newberg, OR 97132, USA.
Gurnho ParkDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, 414 N. Meridian Street, #6088, Newberg, OR 97132, USA.
Taehong KimDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, 414 N. Meridian Street, #6088, Newberg, OR 97132, USA.
Hyoju KimDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, 414 N. Meridian Street, #6088, Newberg, OR 97132, USA.
Timothy ParkDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, 414 N. Meridian Street, #6088, Newberg, OR 97132, USA.
Sydney StaleyDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, 414 N. Meridian Street, #6088, Newberg, OR 97132, USA.
Miriam KangDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, 414 N. Meridian Street, #6088, Newberg, OR 97132, USA.
Youngbok Abraham KangDepartment of Mechanical, Civil, and Biomedical Engineering, George Fox University, 414 N. Meridian Street, #6088, Newberg, OR 97132, USA.ORCID 0000-0002-8562-3797

Funding

George Fox University GFU2023G10
6 · The paper itself

Abstract

Heart-on-a-chip (HoC) platforms represent a cutting-edge convergence of microfluidics and cellular biology, designed to imitate the complex physiological, electrical, and mechanical environments of a human heart. HoC devices are used to culture and observe cardiac cells in a highly customizable environment while allowing for real-time observations. However, current HoC systems face critical translational bottlenecks. Most notably, laboratory-grown cardiomyocytes consistently exhibit structural and functional immaturity and a lack of cellular complexity. This review evaluates recent engineering and biological strategies engineered to address these limitations. We dissect advancements in multicellular co-culture, biomimetic electrical/mechanical stimulation regimes, and microvascular fabrication techniques aimed at driving functional cell maturation. Finally, we highlight current cardiac model applications, existing challenges, and future perspectives.

Indexed as

cardiomyocyteselectrical stimulationheart modelheart-on-a-chipmechanical stimulation

Identifiers

PMID42796198
PMCPMC13609516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.