Evidence map›Paper›PMID 42795673›Full record

ReviewMicroorganisms2026

Microbe-Derived Antimicrobial Peptides: Immunomodulation and Gut Microbiota Homeostasis.

Yanyan Jia, Jiahao Du, Ke Ding, Guyue Li, Chengshui Liao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yanyan JiaLaboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Jiahao DuLaboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.
Ke DingCollege of Animal Science and Technology, Henan Institute of Science and Technology, Xinxiang 453000, China.
Guyue LiCollege of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Chengshui LiaoLaboratory of Functional Microbiology and Animal Health, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, China.

Funding

National Natural Science Foundation of China 32373015Natural Science Foundation of Henan Province 242300421107Outstanding Youth Science and Technology Talent Cultivation Fund of Henan University of Science and Technology 2025HNKJDXYXQNCXRC11Youth Backbone Teachers Training Program of Henan Province 2023GGJS049
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are key components of the innate immune system across a wide range of organisms. In addition to their direct antimicrobial activity, AMPs exert immunomodulatory effects that differ from those of conventional antibiotics. This review summarizes recent evidence on the roles of microbe-derived AMPs in regulating immune cell function, including neutrophil activation and NET formation, macrophage polarization, and lymphocyte proliferation and differentiation. It also examines their organ-specific roles, particularly in intestinal immunity through reinforcement of the intestinal barrier, maintenance of gut microbiota homeostasis, and promotion of sIgA secretion. Together, their direct antimicrobial and immunomodulatory activities support the therapeutic potential of microbe-derived AMPs against drug-resistant infections, cancer, and inflammatory conditions. We synthesize recent evidence on the modulation of innate and adaptive immunity by microbe-derived AMPs. This review provides an integrated framework for understanding how microbe-derived AMPs orchestrate immune defense across cellular, tissue, and systemic levels, with implications for therapeutic development against infectious, inflammatory, and neoplastic diseases.

Indexed as

antimicrobial peptidesimmune cellimmunomodulatoryintestinal immunitymicroorganismspleen

Identifiers

PMID42795673
PMCPMC13609794

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.