Evidence map›Paper›PMID 42795665›Full record

ReviewMicroorganisms2026

Advances in the Production of D-Tagatose Using L-Arabinose Isomerase.

Bingyi Tao, Wei Liu, Ziheng Li, Ren He, Tingting Huang, Shaoxiong Liang, Hongkun Chen, Xiaoping Rao, Xuchong Tang, Jianchun Jiang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bingyi TaoCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Wei LiuCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Ziheng LiCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Ren HeFujian Provincial Key Laboratory of Biomass Low-Carbon Conversion, Academy of Advanced Carbon Conversion Technology, Huaqiao University, Xiamen 361021, China.
Tingting HuangFujian Provincial Key Laboratory of Biomass Low-Carbon Conversion, Academy of Advanced Carbon Conversion Technology, Huaqiao University, Xiamen 361021, China.
Shaoxiong LiangCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Hongkun ChenBaYeCao Health Industry Research Institute Co., Ltd., Xiamen 361021, China.
Xiaoping RaoCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.ORCID 0000-0001-5115-8260
Xuchong TangCollege of Chemical Engineering, Huaqiao University, Xiamen 361021, China.
Jianchun JiangFujian Provincial Key Laboratory of Biomass Low-Carbon Conversion, Academy of Advanced Carbon Conversion Technology, Huaqiao University, Xiamen 361021, China.

Funding

Key Science and Technology Program Project in the Future Industry of Xiamen 3502Z20254020Science and Technology Program Project of Nanping N2023Y015Science and Technology Program Project of Xiamen 3502Z20251003Science and Technology Program Project of Xiamen 3502Z20251008
6 · The paper itself

Abstract

D-tagatose is a rare sugar that occurs naturally and combines high sweetness with a low caloric value. It has several beneficial effects, including anticariogenic activity, modulation of the intestinal microbiota, and potential benefits for diabetes management. It is used as a novel sweetener and pharmaceutical excipient in the food and pharmaceutical industries. Currently, D-tagatose is produced mainly through chemical synthesis and biocatalysis. The chemical preparation of D-tagatose requires complex product purification and entails high waste-treatment costs, while biological preparation of D-tagatose offers high catalytic efficiency, mild reaction conditions, and fewer by-products. Therefore, in recent years, the biocatalytic conversion of D-galactose into D-tagatose using L-arabinose isomerase (L-AI) has attracted considerable attention, prompting extensive efforts to develop more economical and environmentally friendly production methods. To date, L-AI from various microbial sources has been identified and characterized, and researchers have engineered L-AI into a more effective biocatalyst through mutagenesis to improve process feasibility. This paper comprehensively reviews the current status and the latest advancements in the synthesis of D-tagatose from the perspective of biocatalysis.

Indexed as

biocatalysisD-tagatoseL-arabinose isomerase

Identifiers

PMID42795665
PMCPMC13609448

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.