Evidence map›Paper›PMID 42795658›Full record

ArticleMicroorganisms2026

Untargeted Lipidomics Reveals Lipid Alterations in Colonic Contents of C57BL/6J Mice with Acute

Wen-Jie Cheng, Bo-Fang Duan, Cai-Qin Deng, Peng-Hao Wei, Min-Min Sui, Yi-Dan Wang, Xing-Quan Zhu, Feng-Cai Zou, Zhao Li

Abstract read
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In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wen-Jie ChengFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.ORCID 0009-0008-9961-821X
Bo-Fang DuanThe Yunnan Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, China.
Cai-Qin DengThe Yunnan Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, China.
Peng-Hao WeiFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Min-Min SuiFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.
Yi-Dan WangFaculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China.ORCID 0009-0007-9212-3508
Xing-Quan ZhuThe Yunnan Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, China.ORCID 0000-0003-2530-4628
Feng-Cai ZouThe Yunnan Key Laboratory of Veterinary Etiological Biology, College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, China.ORCID 0000-0002-9613-3734
Zhao LiAnimal Research and Resource Center, School of Life Sciences, Yunnan University, Kunming 650500, China.ORCID 0009-0004-7848-0152

Funding

NSFC-Yunnan Joint Fund U2202201Yunnan Fundamental Research Projects 202401AT070440, 202601AT070152Yunnan Key Laboratory of Veterinary Etiological Biology 202449CE340019
6 · The paper itself

Abstract

backgroundAlthough

methodsAn acute infection model was established using C57BL/6J mice by oral inoculation with the

resultsAcute infection significantly elevated glycerophospholipids (GPs) and reduced glycerolipids (GLs), and prenol lipids (PRs), leading to 136 differentially abundant lipids. Pathway enrichment analysis identified the two most significantly affected pathways: choline metabolism in cancer and glycerophospholipid metabolism, with lysophosphatidic acid (LPA(16:0)) and lysophosphatidylcholine (LPC(18:1)) functioning as core hub nodes. Receiver operating characteristic (ROC) analysis identified phosphatidylethanolamine (PE(20:1e_22:4)), PE(16:0_22:6), hexosylceramide (Hex1Cer(m18:0_20:4)), and Hex1Cer(t17:0_22:6) as exploratory candidate biomarkers with high discriminatory performance (AUC > 0.94).

conclusionsAcute

Indexed as

acute infectioncolonic contentslipidomicsToxoplasma gondii

Identifiers

PMID42795658
PMCPMC13608983

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.