Evidence map›Paper›PMID 42795643›Full record

ArticleMicroorganisms2026

Antibiotic Selection for Sustained Local Therapy May Be Important to Reduce

Dustin Williams, Robert Falconer, David Rothberg, Mario Lopez, Jacob Adams, Alice Miller, Richard Tyler Epperson, Brooke Kawaguchi, Caroline Garrett, Paul Pasquina and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dustin WilliamsDepartment of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA.ORCID 0000-0001-5275-1365
Robert FalconerDepartment of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA.
David RothbergDepartment of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA.ORCID 0000-0002-7749-3662
Mario LopezDepartment of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA.
Jacob AdamsNoorda College of Osteopathic Medicine, Provo, UT 84606, USA.
Alice MillerDepartment of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA.
Richard Tyler EppersonDepartment of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA.ORCID 0000-0001-6736-8641
Brooke KawaguchiDepartment of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA.
Caroline GarrettOffice of Comparative Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Paul PasquinaDepartment of Physical Medicine and Rehabilitation, Uniformed Services University, Bethesda, MD 20814, USA.
Nicholas AshtonDepartment of Orthopaedics, University of Utah, Salt Lake City, UT 84108, USA.

Funding

United States Department of Defense W81XWH-20-1-0384
6 · The paper itself

Abstract

Polymicrobial fracture-related infections (FRIs) underpinned by bacterial biofilms pose therapeutic challenges distinct from those of monomicrobial infection, as interspecies dynamics may alter both antimicrobial response and host tissue injury. This study evaluated systemic and local antibiotic strategies in an ovine FRI model co-inoculated with a polymicrobial

Indexed as

bacteriabiofilmfracture-related infectionlocal deliveryPseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID42795643
PMCPMC13609462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.