Evidence map›Paper›PMID 42795568›Full record

ArticleMicroorganisms2026

Targeting the 3C Protease of Hepatitis A Virus Subgenotype IB: Virtual Screening and Identification of Potent Lead Candidates.

Tatsuo Kanda, Reina Sasaki-Tanaka, Hiroaki Okamoto, Shuji Terai, Cole D Cwiklowski, Kalyan C Nagulapalli Venkata

Abstract read
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tatsuo KandaDivision of Gastroenterology and Hepatology, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, 4132 Urasa, Minamiuonuma 949-7302, Japan.ORCID 0009-0000-8135-342X
Reina Sasaki-TanakaDivision of Gastroenterology and Hepatology, Niigata University Graduate School of Medicine, Dentistry and Health Sciences (Medicine), Niigata University, Niigata 951-8510, Japan.
Hiroaki OkamotoDivision of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke 329-0498, Japan.ORCID 0000-0003-0827-0964
Shuji TeraiDivision of Gastroenterology and Hepatology, Niigata University Graduate School of Medicine, Dentistry and Health Sciences (Medicine), Niigata University, Niigata 951-8510, Japan.ORCID 0000-0002-5439-635X
Cole D CwiklowskiDepartment of Medicinal Chemistry, University of Health Sciences and Pharmacy, St. Louis, MO 63010, USA.
Kalyan C Nagulapalli VenkataDepartment of Medicinal Chemistry, University of Health Sciences and Pharmacy, St. Louis, MO 63010, USA.ORCID 0000-0002-7308-014X

Funding

Japan Agency for Medical Research and Development JP25fk0210132Japan Agency for Medical Research and Development JP26fk0210198University of Health Sciences and Pharmacy FRIF-20-134
6 · The paper itself

Abstract

Hepatitis A virus (HAV) infection remains a global public health concern in both developing and developed countries. In the present study, we identified anti-HAV drugs, using AutoDock Vina Modeling software, and evaluated the compounds in vitro. Following cytotoxicity for Huh7 cells, 5 out of 10 compounds were selected. We evaluated effective HAV 3C protease inhibitors with activity against both HAV genotype IB HM175/18f and HAV genotype IIIA HA11-1299-infected human hepatoma cells. Among the five compounds, we identified only one (

Indexed as

drug discoveryHA11-1299HAV 3C protease inhibitorshepatitis A virusin silico

Identifiers

PMID42795568
PMCPMC13609847

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.