Evidence map›Paper›PMID 42795543›Full record

ArticleMicroorganisms2026

Genetic Diversity, Phylogenetic Lineages, and Antigenic Features of the PRRSV-1 GP5 Gene in China.

Fang Liang, Tianyuan Nie, Peixiu Lin, Huawei Li, Ruining Wang, Xuyong Zhao, Lin Wang, Keshan Zhang, Yaqiong Ye, Mengmeng Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fang LiangSchool of Animal Science and Technology, Foshan University, Foshan 528225, China.
Tianyuan NieSchool of Animal Science and Technology, Foshan University, Foshan 528225, China.
Peixiu LinSchool of Animal Science and Technology, Foshan University, Foshan 528225, China.
Huawei LiCollege of Veterinary Medicine, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Ruining WangCollege of Veterinary Medicine, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Xuyong ZhaoCollege of Veterinary Medicine, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Lin WangInstitute of Cancer Sciences, University of Glasgow, Glasgow G12 800, UK.
Keshan ZhangSchool of Animal Science and Technology, Foshan University, Foshan 528225, China.ORCID 0009-0002-0306-0327
Yaqiong YeSchool of Animal Science and Technology, Foshan University, Foshan 528225, China.
Mengmeng ZhaoSchool of Animal Science and Technology, Foshan University, Foshan 528225, China.ORCID 0000-0003-4143-3606

Funding

Base and Talent Program of Science and Technology Plan in Tibet Autonomous Region XZ202401JD0012Foshan University 2025 Graduate Excellence and Innovation Program FOSU2025ZYCX-M04Foshan University High Level Talents Research Start-up Project CGZ07465/CGZ07001Guangdong Basic and Applied Basic Research Foundation 2024A1515140152Guangdong Provincial Department of Education's distinctive innovation initiative 2023KTSCX128Key Research and Development Special Project of Henan Province 251111113600Key Scientific and Technological Grants in Henan Province 24210211031National Key Research and Development Program Projects 2023YFD1801302, 2023YFD1801301National Natural Science Foundation of China 31902279Open Foundation of Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding 2024B03Special Funds for Rural Revitalization Strategy of Guangdong Provincial Department of Agricul-ture and Rural Affairs in 2024 2024CXTD15
6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) poses a significant threat to the global swine industry. In this study, the genetic diversity, evolutionary dynamics, and key antigenic characteristics of the PRRSV-1 GP5 gene in China were systematically investigated. A total of 114 Chinese PRRSV-1 GP5 sequences, isolated between 1999 and 2024, were analyzed alongside global reference strains. The nucleotide and amino acid sequence similarities ranged from 60.03% to 100% and from 48.72% to 100%, respectively, with mutation and deletion hotspots concentrated in the N-terminal hypervariable region. Phylogenetic analysis further classified the Chinese strains into four major lineages: Amervac-like, BJEU06-1-like, HKEU16-like, and NMEU09-1-like. Notably, a preliminary phylogenetic observation indicated that several recent Chinese PRRSV-1 isolates clustered topologically close to PRRSV-2 strains. However, as this finding is based solely on a single-gene tree and has not been validated by formal tests for convergent evolution, homoplasy, or selection pressure, it should be interpreted with caution and warrants further investigation using whole-genome data. A Bayesian evolutionary analysis estimated the evolutionary rate at 1.94 × 10

Indexed as

antigenic epitopesgenetic variationGP5 genephylogenetic evolutionPRRSV-1

Identifiers

PMID42795543
PMCPMC13608930

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