Evidence map›Paper›PMID 42795442›Full record

ArticleLife (Basel, Switzerland)2026

Extracorporeal Multiorgan Support During Prone Positioning in Severe ARDS: A Physiologic Proof-of-Concept Study.

Tobias Lahmer, Eva Ortner, Aritz Perez Ruiz de Garibay, Luigi Camporota, Bernd Panholzer, Roland M Schmid, Johanna Erber, Fabian Kleinhenz, Luis Hinterwaldner, Lailai Qu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tobias LahmerTUM School of Medicine and Health, Clinical Department of Internal Medicine II, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.
Eva OrtnerTUM School of Medicine and Health, Clinical Department of Internal Medicine II, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.ORCID 0009-0002-6722-460X
Aritz Perez Ruiz de GaribayIdazmed Consulting SL, 01006 Vitoria-Gasteiz, Spain.ORCID 0000-0002-1022-525X
Luigi CamporotaDivision of Anaesthetics, Pain Medicine and Intensive Care (APMIC), Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London W12 0NN, UK.ORCID 0009-0000-3983-9055
Bernd PanholzerDepartment for Cardiac Surgery, University Hospital Schleswig-Holstein, 24105 Kiel, Germany.ORCID 0000-0002-4992-818X
Roland M SchmidTUM School of Medicine and Health, Clinical Department of Internal Medicine II, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.
Johanna ErberTUM School of Medicine and Health, Clinical Department of Internal Medicine II, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.ORCID 0000-0001-6614-6051
Fabian KleinhenzTUM School of Medicine and Health, Clinical Department of Internal Medicine II, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.
Luis HinterwaldnerTUM School of Medicine and Health, Clinical Department of Internal Medicine II, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.
Lailai QuTUM School of Medicine and Health, Clinical Department of Internal Medicine II, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.
Julian TriebelhornTUM School of Medicine and Health, Clinical Department of Internal Medicine II, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.
Miriam DibosTUM School of Medicine and Health, Clinical Department of Internal Medicine II, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.ORCID 0000-0001-7778-3283
Ulrich MayrTUM School of Medicine and Health, Clinical Department of Internal Medicine II, TUM University Hospital, Ismaninger Str. 22, 81675 Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProne positioning and lung-protective ventilation are key components of the management of moderate-to-severe acute respiratory distress syndrome (ARDS). However, protective ventilation may be limited by refractory hypercapnia, acidosis, and hemodynamic instability. Whether extracorporeal multiorgan support can complement prone positioning by alleviating these physiologic constraints remains unknown.

methodsWe conducted a retrospective physiologic cohort study of adult patients with severe ARDS treated with prone positioning combined with extracorporeal multiorgan support using the ADVOS system. The cohort represented a highly selected population with bacterial pneumonia-associated ARDS, sepsis, acute kidney injury, and vasopressor dependence. Physiologic variables were recorded from baseline to the end of the first (t16) and second (t40) prone sessions. The primary objective was to assess short-term changes in arterial pH, PaCO

resultsFifteen patients were included. Median baseline PaCO

conclusionsIn this highly selected cohort, combined prone positioning and extracorporeal multiorgan support was associated with rapid correction of hypercapnic acidosis, improved oxygenation, and favorable changes in selected measures of ventilatory load. These findings describe the integrated physiologic response to the combined strategy and warrant evaluation in prospective controlled studies.

Indexed as

acute respiratory distress syndromeadvanced organ supportextracorporeal carbon dioxide removalhypercapniamechanical ventilationprone positioning

Identifiers

PMID42795442
PMCPMC13608018

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.