ArticleLife (Basel, Switzerland)2026
Clinical Outcomes of Respiratory Syncytial Virus Versus Influenza Pneumonia in Critically Ill Adults.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRespiratory syncytial virus (RSV) and influenza can both cause severe viral pneumonia requiring intensive care. Influenza is supported by established vaccination programs and antiviral therapy, whereas outcomes of RSV infection among critically ill adults remain less well characterized. This study compared clinical presentation, treatment, and outcomes between ICU admissions classified as RSV pneumonia and those classified as influenza pneumonia.
methodsA retrospective cohort was assembled from MIMIC-IV data covering 2008-2019. The analytical cohort comprised 201 infection-specific ICU observations classified as RSV pneumonia (
resultsThe RSV group was older than the influenza group (66.7 vs. 59.1 years;
conclusionsRSV pneumonia was associated with higher in-hospital mortality and a longer ICU stay than influenza pneumonia in this ICU cohort. The mortality association remained after adjustment for the variables included in the primary model, although its magnitude was sensitive to model specification. Given the observational design, these findings should not be interpreted as causal. They underscore the clinical burden of severe RSV infection in adults and support further investigation in larger cohorts with standardized virological testing and measures of acute illness severity.
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