Evidence map›Paper›PMID 42795372›Full record

ArticleLife (Basel, Switzerland)2026

Predictors of Metastatic Lymph Node Burden in Colorectal Cancer: A Negative Binomial Regression Analysis.

Laurențiu Augustus Barbu, Stelian-Stefaniță Mogoantă, Tiberiu Stefăniță Țenea Cojan, Nicolae-Dragoș Mărgăritescu, Cecil Sorin Mirea, Marius Cristian Marinaș, Liviu Vasile

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Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laurențiu Augustus BarbuDepartment of Surgery, Railway Clinical Hospital Craiova, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.ORCID 0009-0008-5822-8805
Stelian-Stefaniță MogoantăDepartment of Surgery, Emergency County Hospital, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
Tiberiu Stefăniță Țenea CojanDepartment of Surgery, Railway Clinical Hospital Craiova, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
Nicolae-Dragoș MărgăritescuDepartment of Surgery, Emergency County Hospital, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
Cecil Sorin MireaDepartment of Surgery, Emergency County Hospital, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.
Marius Cristian MarinașDepartment of Human Anatomy, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.ORCID 0009-0007-9672-1281
Liviu VasileDepartment of Surgery, Emergency County Hospital, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania.ORCID 0000-0002-7018-5675

Funding

University of Medicine and Pharmacy of Craiova N/A
6 · The paper itself

Abstract

backgroundThe prognostic value of preoperative inflammatory and nutritional biomarkers in colorectal cancer has been extensively investigated, but their association with metastatic lymph node burden remains insufficiently explored. This study evaluated whether routinely available biomarkers are associated with the number of metastatic lymph nodes in patients undergoing colorectal cancer resection.

methodsWe retrospectively analyzed 935 consecutive patients who underwent colorectal cancer surgery between 2020 and 2024. Preoperative hemoglobin, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and Prognostic Nutritional Index (PNI) were assessed. Negative binomial regression was used to model metastatic lymph node count, with sensitivity analyses accounting for surgical setting and total lymph node yield.

resultsIn the fully adjusted primary model, tumor location (

conclusionsLymphovascular invasion showed the most robust association with metastatic lymph node burden. Although PNI showed a modest association in the primary model, it provided no significant incremental improvement in model fit, while tumor-location associations were sensitive to model specification. These findings require validation in independent cohorts.

Indexed as

colorectal cancerimmunonutritioninflammatory biomarkerslymph node metastasisnegative binomial regressionprognostic nutritional index (PNI)

Identifiers

PMID42795372

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.