ArticleLife (Basel, Switzerland)2026
Differential Modulation of Extracellular Matrix- and Longevity-Related Gene Expression by Calcium Hydroxylapatite Formulations.
Article in Life (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesCalcium hydroxylapatite (CaHA) is widely used in aesthetic medicine as a biostimulatory dermal filler. While its ability to induce neocollagenesis is well established, its broader transcript-level effects on fibroblast biology under aging-like conditions remain incompletely characterized. This study aimed to compare the gene-expression responses induced by three commercially available CaHA formulations in an EX-527-induced aging-like human dermal fibroblast model.
methodsAn aging-like fibroblast phenotype was induced in primary human dermal fibroblasts using the SIRT1 inhibitor EX-527, which was maintained in culture throughout the CaHA treatment period. Cells were exposed to three commercially available CaHA formulations (D, R, S) for 72 h. Gene expression was assessed by RT-qPCR, evaluating markers related to extracellular matrix remodeling,
resultsAll CaHA formulations induced upregulation of
conclusionsThese transcript-level findings suggest that CaHA exposure is associated with differential gene-expression responses involving markers related to extracellular matrix remodeling, inflammatory and regulatory signaling, mitochondrial stress response, and longevity-associated pathways. Functional and protein-level validation will be required to determine whether these transcriptional changes translate into meaningful biological effects in more complex models of aging skin.
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