Evidence map›Paper›PMID 42794995›Full record

ArticleCancers2026

Tumor Inflammation Confounds Radiographic Determination of Extranodal Extension in HPV-Associated Head and Neck Squamous Cell Carcinoma.

Sri Vemulamanda, Yasine Mirmozaffari, Alan H Zhao, Noman Khan, Wendell G Yarbrough, Natalia Issaeva, Benjamin Y Huang, Travis P Schrank

Abstract read
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sri VemulamandaDepartment of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, Chapel Hill, NC 27599, USA.
Yasine MirmozaffariDepartment of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, Chapel Hill, NC 27599, USA.ORCID 0009-0002-2529-2161
Alan H ZhaoDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Noman KhanDepartment of Radiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Wendell G YarbroughDepartment of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, Chapel Hill, NC 27599, USA.ORCID 0000-0003-0855-6444
Natalia IssaevaDepartment of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, Chapel Hill, NC 27599, USA.ORCID 0000-0001-5483-6610
Benjamin Y HuangDepartment of Radiology, University of North Carolina, Chapel Hill, NC 27599, USA.
Travis P SchrankDepartment of Otolaryngology/Head and Neck Surgery, UNC School of Medicine, Chapel Hill, NC 27599, USA.ORCID 0000-0002-8297-3329

Funding

Yale Head and Neck Cancer SPORE: Overcoming Treatment Resistance in Head and Neck CancerP50DE030707 · NIDCR · YALE UNIVERSITY · PI FERGUSON, KATHRYN M · 2020 to 2024
$11.8M
Observational study to validate circulating HPVDNA and prognostic genomic biomarkers for diagnosis and treatment of HPV-associated OPSCCU01DE029754 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ISSAEVA, NATALIA, YARBROUGH, WENDELL G · 2020 to 2024
$3.8M
Exploring mechanisms of therapeutic demethylation effects in HPV-associated head and neck cancerR01DE027942 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANDERSON, KAREN S., ISSAEVA, NATALIA · 2019 to 2023
$2.1M
Dissecting NF-kB pathway in HPV-associated head and neck cancerR01DE031297 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Natalia Issaeva, WENDELL G YARBROUGH · 2023 to 2026
$2.0M
Mechanisms Determining Dysregulation of the NRF2 Oxidative Stress Response in Head and Neck Squamous Cell CarcinomaK08DE029241 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SCHRANK, TRAVIS P. · 2020 to 2024
$870k
NIDCR NIH HHS K08 DE029241NIDCR NIH HHS K08-DE029241-01ANIDCR NIH HHS P50 DE030707NIDCR NIH HHS R01 DE027942NIDCR NIH HHS R01DE027942NIDCR NIH HHS R01 DE031297NIDCR NIH HHS R01DE031297NIDCR NIH HHS U01 DE029754NIDCR NIH HHS U01DE029754
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

bioinformaticsextranodal extensionHPV-associated HNSCCmachine learningoropharyngeal squamous cell carcinomaRNA sequencingtumor inflammation

Identifiers

PMID42794995
PMCPMC13605798

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.