Evidence map›Paper›PMID 42794957›Full record

ArticleCancers2026

Nuclear Factor-κB Signaling in Murine Models of Malignant Pleural Mesothelioma.

Benteng Deng, Ioanna Giopanou, Lori Asarian, Ioannis Lilis, Jianlong Jia, Marina Lianou, Dimitris Simoglou, Giannoula Ntaliarda, Tonia A Adamide, Isis E Fernandez and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Benteng DengInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, German Center for Lung Research (DZL), 81377 Munich, Bavaria, Germany.ORCID 0009-0008-1969-757X
Ioanna GiopanouLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Achaia, Greece.
Lori AsarianInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, German Center for Lung Research (DZL), 81377 Munich, Bavaria, Germany.ORCID 0000-0003-1776-6056
Ioannis LilisLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Achaia, Greece.
Jianlong JiaInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, German Center for Lung Research (DZL), 81377 Munich, Bavaria, Germany.
Marina LianouLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Achaia, Greece.
Dimitris SimoglouLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Achaia, Greece.
Giannoula NtaliardaLaboratory for Molecular Respiratory Carcinogenesis, Department of Physiology, Faculty of Medicine, University of Patras, 26504 Rio, Achaia, Greece.ORCID 0000-0002-2299-6027
Tonia A AdamideDepartment of Pulmonary Medicine, Nicosia General Hospital, Strovolos 2031, Nicosia, Cyprus.
Isis E FernandezInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, German Center for Lung Research (DZL), 81377 Munich, Bavaria, Germany.
Georgios T StathopoulosInstitute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Zentrum München, German Center for Lung Research (DZL), 81377 Munich, Bavaria, Germany.ORCID 0000-0002-9215-6461

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalignant pleural mesothelioma (MPM) is an aggressive asbestos-associated cancer in which inflammatory pathways may contribute to tumor behavior. NF-κB signaling is a central mediator of inflammation and cell survival, but the relative contributions of its associated enzymes, IKKα- and IKKβ, in MPM models remain incompletely understood.

methodsWe characterized the involvement of IKKα- and IKKβ in tumor formation using several in vitro approaches and the intrapleural or subcutaneous delivery of three murine MPM cell models (AB2, AE17 and KPM1). The experimental approaches included shRNA silencing of

resultsActivation of the IKKα- and IKKβ was confirmed in the AB2, AE17 and KPM1 cell lines. Silencing both

conclusionsOur data support the involvement of IKK/NF-κB-associated signaling in cell survival, clonogenicity and tumor growth in several MPM murine cell models and identify

Indexed as

ChukIkbkbIKKαIKKβmalignant pleural mesotheliomamurine tumor modelsNF-κBRNA-seqshRNA

Identifiers

PMID42794957
PMCPMC13605877

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.