Evidence map›Paper›PMID 42794858›Full record

ArticleInternational journal of molecular sciences2026

Bioactive Conjugate Based on Bacterial Protein Toxins for Targeted Down-Modulation of Macrophage Functions.

Johanna Diehm, Marie Jachmann, Joscha Borho, Robin Schönegg, Anna Elbe, Marc Spitzmüller, Michael Fauler, Manfred Frick, Holger Barth

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Johanna DiehmInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University of Ulm Medical Center, 89081 Ulm, Germany.
Marie JachmannInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University of Ulm Medical Center, 89081 Ulm, Germany.
Joscha BorhoInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University of Ulm Medical Center, 89081 Ulm, Germany.
Robin SchöneggInstitute for General Physiology, University of Ulm, 89081 Ulm, Germany.
Anna ElbeInstitute for General Physiology, University of Ulm, 89081 Ulm, Germany.
Marc SpitzmüllerInstitute for General Physiology, University of Ulm, 89081 Ulm, Germany.
Michael FaulerInstitute for General Physiology, University of Ulm, 89081 Ulm, Germany.ORCID 0000-0002-7371-849X
Manfred FrickInstitute for General Physiology, University of Ulm, 89081 Ulm, Germany.ORCID 0000-0002-4763-1104
Holger BarthInstitute of Experimental and Clinical Pharmacology, Toxicology and Pharmacology of Natural Products, University of Ulm Medical Center, 89081 Ulm, Germany.

Funding

Deutsche Forschungsgemeinschaft 251293561
6 · The paper itself

Abstract

Targeted down-modulation of monocytes and macrophages is a promising strategy for controlling excessive inflammatory processes. Bacterial protein toxins are attractive pharmacological modulation tools for this purpose because of their potency and specificity. Here, we combined the specific properties of the two protein toxins C3lim from

Indexed as

Adenylate Cyclase ToxinBacterial ToxinsMacrophagesBordetella pertussisCell MovementCyclic AMPHeLa CellsHumansMonocytesAdenylate Cyclase ToxinBacterial ToxinsCyclic AMPbacterial protein toxinsC3limcAMPchemotaxisCyaA toxindown-modulationmacrophagesmigrationmonocytestargeted delivery

Identifiers

PMID42794858
PMCPMC13607279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.