Novel Fluorophenylated Dihydroimidazotriazinones as Potential Anticancer Agents: Design, Synthesis, In Vitro, Ex Vivo and In Silico Characterisation.

Małgorzata Sztanke, Jolanta Rzymowska, Małgorzata Janicka, Weronika Sofińska-Chmiel, Krzysztof Sztanke

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Małgorzata SztankeDepartment of Medical Chemistry, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland.ORCID 0000-0003-1576-097X

Jolanta RzymowskaDepartment of Biology and Genetics, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland.

Małgorzata JanickaDepartment of Physical Chemistry, Institute of Chemical Science, Faculty of Chemistry, Maria Curie-Skłodowska University, Maria Curie-Skłodowska Sq. 3, 20-031 Lublin, Poland.

Weronika Sofińska-ChmielAnalytical Laboratory, Institute of Chemical Science, Faculty of Chemistry, Maria Curie-Skłodowska University, Maria Curie-Skłodowska Sq. 3, 20-031 Lublin, Poland.

Krzysztof SztankeLaboratory of Bioorganic Compounds Synthesis and Analysis, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, Poland.ORCID 0000-0002-1898-5245

Funding

Medical University of Lublin DS 701Medical University of Lublin DS 702

6 · The paper itself

Abstract

This article describes the synthesis, structure confirmation, and evaluation of physico-chemical, pharmacological, and pharmacokinetic properties of new

Indexed as

Antineoplastic AgentsDrug DesignTriazinesAnimalsApoptosisCell Line, TumorCell ProliferationComputer SimulationHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsTriazinesadenosine A2A and A2B receptor antagonismADME profilingapoptotic caspase levelsdrug candidatesex vivo haemolytic and antihaemolytic activityfluorine–hydrogen isosterismfluorophenylated dihydroimidazotriazinonesin vitro anticancer activitylipophilicity and in silico descriptorsmolecular target

Identifiers

PMID42794815

DOI10.3390/ijms27188388

PMCPMC13607122

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.