SynthesisInternational journal of molecular sciences2026
Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Sucralose is a widely consumed non-nutritive sweetener, with approximately 85% reaching the colon unmetabolized and directly interacting with the gut microbiota. Despite regulatory approval, its impact on microbial ecology and metabolic outcomes remains inconclusive. Previous meta-analyses included only two human studies and did not integrate microbiota, short-chain fatty acids, and metabolic parameters. This systematic review and meta-analysis evaluated the effects of sucralose on gut microbiota composition, alpha diversity, short-chain fatty acid production, and metabolic parameters in healthy adults based on randomized controlled trial evidence. A systematic search of PubMed, Scopus, and Google Scholar was conducted in May 2026 following PRISMA guidelines. Risk of bias was assessed using Cochrane RoB 2.0, and meta-analysis employed a REML random-effects model. Ten randomized controlled trials involving 8-61 participants per study (total across intervention and control groups) met the inclusion criteria; seven provided data for meta-analysis. Sucralose did not significantly alter alpha diversity (Shannon index: SMD = -0.00; 95% CI -1.16 to 1.15;
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