Evidence map›Paper›PMID 42794783›Full record

ReviewInternational journal of molecular sciences2026

Apoptosis Modulation by LL-37: From Mitochondrial Cell Death to Prosurvival Signaling.

Olga Evgenevna Voronko, Vitalia Sergeevna Novikova, Olesya Olegovna Klychkova, Margarita Pavlovna Markina, Arthur Anatolievich Lee, Dmitry Alexandrovich Kashirskikh, Victoria Alexandrovna Khotina, Vagif Ali Oglu Gasanov

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Olga Evgenevna VoronkoKoltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia.
Vitalia Sergeevna NovikovaKoltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia.
Olesya Olegovna KlychkovaKoltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia.ORCID 0009-0000-1308-4942
Margarita Pavlovna MarkinaKoltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia.
Arthur Anatolievich LeeKoltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia.ORCID 0009-0001-3341-4248
Dmitry Alexandrovich KashirskikhKoltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia.ORCID 0000-0002-0748-9238
Victoria Alexandrovna KhotinaKoltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia.ORCID 0000-0003-2096-3237
Vagif Ali Oglu GasanovKoltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow 119334, Russia.

Funding

The Ministry of Education and Science of the Russian Federation 0088-2025-0004
6 · The paper itself

Abstract

This review summarizes current knowledge on the role of human cathelicidin LL-37 in the regulation of apoptosis. LL-37 can modulate programmed cell death pathways, exerting either proapoptotic or antiapoptotic effects depending on various factors, such as cell type and peptide concentration. Data on LL-37 derivatives and their involvement in apoptosis are also discussed. Understanding the molecular mechanisms underlying LL-37 regulation of apoptosis is necessary to expand the therapeutic potential of this peptide in various pathological conditions, including cancer.

Indexed as

Antimicrobial Cationic PeptidesApoptosisMitochondriaSignal TransductionAnimalsAntimicrobial PeptidesCathelicidinsHumansAntimicrobial Cationic PeptidesAntimicrobial PeptidesCathelicidinsantimicrobial peptides (AMP)apoptosiscell deathhuman cathelicidinLL-37

Identifiers

PMID42794783
PMCPMC13607288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.