ArticleInternational journal of molecular sciences2026
Estimating the Prevalence of Malignant Hyperthermia Susceptibility Based on Causative
Ekaterina Efremova, Elena Baranova, Anton Esibov, Anastasiia Rozhkova, Ekaterina Rutkovskaya, Julia Krupinova, Olga Mityaeva, Mary Woroncow, Sherzod Abdullaev, Karin Mirzaev and 3 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Ekaterina EfremovaPetrovsky National Research Center of Surgery, Moscow 119435, Russia.
Elena BaranovaPetrovsky National Research Center of Surgery, Moscow 119435, Russia.
Anton EsibovFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow 125315, Russia.
Anastasiia RozhkovaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow 125315, Russia.ORCID 0009-0006-7876-1223 Ekaterina RutkovskayaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow 125315, Russia.
Julia KrupinovaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow 125315, Russia.
Olga MityaevaFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow 125315, Russia.ORCID 0000-0001-9252-1601 Mary WoroncowFaculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow 119991, Russia.
Karin MirzaevPetrovsky National Research Center of Surgery, Moscow 119435, Russia.
Viktor BogdanovFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow 125315, Russia.ORCID 0000-0001-6377-9056 Pavel VolchkovFederal Research Center for Innovator and Emerging Biomedical and Pharmaceutical Technologies, Moscow 125315, Russia.ORCID 0000-0001-9794-6297 Funding
Ministry of Science and Higher Education of the Russian Federation 075-15-2025-463
6 · The paper itselfAbstract
Malignant hyperthermia susceptibility (MHS; OMIM 145600, 601887) is a pharmacogenetic condition in which exposure to volatile anesthetics and/or succinylcholine can trigger a potentially life-threatening hypermetabolic crisis of skeletal muscle. MHS is predominantly associated with pathogenic variants in
Indexed as
Calcium ChannelsGenetic Predisposition to DiseaseMalignant HyperthermiaRyanodine Receptor Calcium Release ChannelCalcium Channels, L-TypeGene FrequencyGenetic VariationHumansPrevalenceCACNA1S protein, humanCalcium ChannelsCalcium Channels, L-TypeRyanodine Receptor Calcium Release ChannelRYR1 protein, humanCACNA1Sgenetic variantsmalignant hyperthermiaRYR1susceptibilityvariant frequencies
Identifiers
PMID42794754
PMCPMC13607192
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