Per- and Polyfluoroalkyl Substances and Papillary Thyroid Carcinoma: An Integrative Study of Bioinformatics, Epidemiological Associations, and In Vitro Responses.

Yuxin Yan, Hongguang Sun, Meili Cong, Xinxin Qi, Shilei Zhang, Tao Liu

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuxin YanSchool of Public Health, Xinjiang Medical University, Urumqi 830054, China.ORCID 0009-0001-8791-0124

Hongguang SunSchool of Public Health, Xinjiang Medical University, Urumqi 830054, China.

Meili CongSchool of Public Health, Xinjiang Medical University, Urumqi 830054, China.ORCID 0009-0008-6760-0314

Xinxin QiSchool of Public Health, Xinjiang Medical University, Urumqi 830054, China.ORCID 0000-0001-5945-6289

Shilei ZhangSchool of Public Health, Xinjiang Medical University, Urumqi 830054, China.

Tao LiuSchool of Public Health, Xinjiang Medical University, Urumqi 830054, China.

Funding

Xinjiang Medical University

6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) have been associated with thyroid dysfunction, but their relationship with papillary thyroid carcinoma (PTC) and relevant molecular processes remains unclear. We integrated bioinformatics analyses, a hospital-based case-control study, and in vitro experiments to investigate associations between PFAS exposure and PTC and to explore potentially relevant post-transcriptional RNA regulatory processes. Transcriptomic data, PFAS-associated genes, and m

Indexed as

Computational BiologyFluorocarbonsThyroid Cancer, PapillaryThyroid NeoplasmsAdultCase-Control StudiesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMiddle AgedFluorocarbonsEIF4Em7G-associated RNA regulationNCBP1papillary thyroid carcinomaper- and polyfluoroalkyl substancesPFAS mixtures

Identifiers

PMID42794724

DOI10.3390/ijms27188296

PMCPMC13607646

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.