Evidence map›Paper›PMID 42794678›Full record

ArticleInternational journal of molecular sciences2026

ADAR1 and ADAR2 Expression in the Thoracic Aortic Wall Correlates with Aneurysm Severity and Dissection Risk: Insights into A-to-I RNA Editing Dysregulation in Marfan Syndrome-Derived vSMCs.

Calogera Pisano, Ambra Colopi, Domenico Alessandro Silvestris, Sonia Terriaca, Eugenia Guida, Annamaria Porreca, Adriana Sbrigata, Paolo Niccolò Doronzio, Augusto Orlandi, Susanna Dolci and 2 more

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Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

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12 authors.

Calogera PisanoCardiac Surgery Unit, Department of Precision Medicine in Medical Surgical and Critical Area (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy.
Ambra ColopiDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0003-1581-0527
Domenico Alessandro SilvestrisDepartment of Biosciences, Biotechnologies and Environment, University of Bari "Aldo Moro", 70126 Bari, Italy.
Sonia TerriacaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
Eugenia GuidaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.
Annamaria PorrecaDepartment of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, 00166 Rome, Italy.ORCID 0000-0003-3278-1561
Adriana SbrigataCardiac Surgery Unit, Department of Precision Medicine in Medical Surgical and Critical Area (Me.Pre.C.C.), University of Palermo, 90127 Palermo, Italy.ORCID 0009-0000-3384-4363
Paolo Niccolò DoronzioDepartment of Life Sciences and Public Health, Section of Genomic Medicine, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0003-2554-4023
Augusto OrlandiDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-7202-5854
Susanna DolciDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0002-6864-3673
Piergiorgio La RosaDepartment of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, 00168 Rome, Italy.ORCID 0000-0002-9723-2363
Valeriana CesariniInstitute of Genetic and Biomedical Research (IRGB), National Research Council of Italy, Milan Unit, 20138 Milan, Italy.ORCID 0000-0001-9323-1796

Funding

Sapienza University of Rome RM12117A86B 6FF27
6 · The paper itself

Abstract

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR1 and ADAR2, is an epitranscriptomic mechanism with emerging roles in cardiovascular disease. We investigated ADAR expression, clinical correlates, A-to-I RNA editing signatures, transcriptome and miRNA targetome in thoracic aortic aneurysm (TAA), focusing on Marfan syndrome (MFS). Immunohistochemical analysis of 58 TAA specimens (18 MFS-associated TAA, 19 tricuspid aortic valve-associated TAA (TAV), 21 bicuspid aortic valve-associated TAA (BAV)) showed the highest ADAR1 and ADAR2 in MFS. ADAR2 in vascular smooth muscle cells (vSMCs) correlated positively with aortic diameter across subtypes; ADAR1 inversely correlated with sinotubular junction dimension in MFS. Transcriptomic profiling of MFS-derived vSMC cultures identified 30 differentially expressed genes enriched in immune activation, impaired RTK signaling, and vSMC reprogramming. RNA editing analysis revealed 77 differentially edited sites across 65 genes, predominantly hypoedited in MFS, including four protein-coding recoding events at

Indexed as

Adenosine DeaminaseAorta, ThoracicAortic Aneurysm, ThoracicMarfan SyndromeMuscle, Smooth, VascularRNA-Binding ProteinsRNA EditingAdenosineDissection, Thoracic AortaFemaleGene Expression ProfilingHumansInosineMaleMicroRNAsMyocytes, Smooth MuscleADARB1 protein, humanADAR protein, humanAdenosineAdenosine DeaminaseInosineMicroRNAsRNA-Binding ProteinsADAR1ADAR2A-to-I RNA editingepitranscriptomicsMarfan syndromemiRNA retargetingthoracic aortic aneurysmvascular smooth muscle cells

Identifiers

PMID42794678
PMCPMC13607941

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.