A Soy-Derived Isoflavone Genistein Inhibits the Life Cycle of PRRSV In Vitro.

Dan Cao, Changchao Huan, Xiaofei Tang, Yongguo Xue

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Dan CaoSoybean Research Institute, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.

Changchao HuanInstitute of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.ORCID 0000-0002-9904-8893

Xiaofei TangSoybean Research Institute, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.

Yongguo XueSoybean Research Institute, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China.

Funding

Research Expenses of Provincial Research Institutes of Heilongjiang Province CZKYF2023-1-C002The Evaluation, Innovation, and Excellent Gene Excavation for Elite Soybean Cultivars between China and Europe 2019YFE0105900

6 · The paper itself

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) has become a global health threat for swine. Because of the limited effectiveness of commercial vaccine strategies and the absence of specific antiviral chemical drugs for PRRS, it is urgent to identify new strategies for preventing and controlling PRRSV infections. Genistein, a soy-derived isoflavone, has shown promise in reducing viremia in PRRSV-infected pigs. However, its antiviral molecular mechanism remains unclear. This study investigates the inhibitory effects and mechanism of genistein on PRRSV infection in vitro. Our results demonstrated that genistein dose-dependently inhibited PRRSV infection in Marc-145 cells at several stages of the PRRSV replication cycle. With its favorable safety profile and potent efficacy in antiviral and growth promotion in swine, genistein stands out as a promising dietary adjunct for PRRSV prevention and control in swine husbandry.

Indexed as

Antiviral AgentsGenisteinGlycine maxPorcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusAnimalsAutophagyCell LineChlorocebus aethiopsSwineVirus ReplicationAntiviral AgentsGenisteinantiviral mechanismautophagygenisteinPRRSVSoybean

Identifiers

PMID42794663

DOI10.3390/ijms27188235

PMCPMC13607109

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.