ArticleInternational journal of molecular sciences2026
Identification of Four Compounds with S-RBD-Binding and Pseudovirus Entry-Inhibitory Activity.
Jingjie Zheng, Shitao Wang, Yuqing Zhou, Qiman Lin, Jingsong Guan, Yao Wang, Jianglin Fan
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
7 authors.
Jingjie ZhengGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China.ORCID 0009-0001-4523-1035 Shitao WangGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China.ORCID 0009-0004-4537-2606 Yuqing ZhouGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China.
Qiman LinGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China.
Jingsong GuanGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China.
Yao WangEngineering Research Center in Ministry of Education for Innovative Drugs of Traditional Chinese Medicine and Zhuang Yao Medicine, Guangxi University of Chinese Medicine, Nanning 530001, China.ORCID 0000-0002-4215-6092 Jianglin FanGuangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, China.ORCID 0000-0002-1737-6130 Funding
Guangdong Province Key Program of Discipline 2021ZDJS091National Key Research and Development Program of China 2022YFA1105403Science and Technology Planning Project of Guangdong Province 2021A1515110916Wuyi University-Hong Kong-Macao Joint Research and Development Fund 2022WGALH14
6 · The paper itselfAbstract
COVID-19, caused by SARS-CoV-2, remains a global health challenge because of viral evolution and immune escape. Although current therapies primarily target viral entry and replication, agents that directly interfere with the Spike receptor-binding domain (S-RBD) remain limited. Here, we combined virtual screening with biological validation to identify compounds capable of interfering with S-RBD function. A total of 3014 compounds from a customized drug library were screened by molecular docking. Candidate binding and functional activity were subsequently evaluated using cellular thermal shift assays, surface plasmon resonance, immunoprecipitation, immunofluorescence, and pseudovirus-entry assays against 2019-nCoV, Delta, and Omicron pseudoviruses. DOTAP chloride (K
Indexed as
Antiviral AgentsSpike Glycoprotein, CoronavirusVirus InternalizationBinding SitesHumansMelittenMolecular Docking SimulationProtein BindingSARS-CoV-2Antiviral AgentsMelittenSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2molecular dockingpseudovirus entry inhibitionSARS-CoV-2 variantsspike receptor-binding domain
Identifiers
PMID42794572
PMCPMC13607727
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