Evidence map›Paper›PMID 42794503›Full record

ArticleInternational journal of molecular sciences2026

Dose-Dependent Hepatotoxicity of Zinc Oxide Nanoparticles in Rats: Oxidative Stress, Apoptosis, and Dysregulation of Hepatic miR-122, miR-34a, and miR-21.

Rasha Muzahem Hatem

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Rasha Muzahem HatemDepartment of Biology, College of Science, University of Al-Qadisiyah, Al-Diwaniyah 58001, Iraq.ORCID 0000-0002-1416-0801

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc oxide nanoparticles (ZnO NPs) are widely used in biomedical, agricultural, and industrial applications, raising concerns about their potential hepatotoxicity. This study investigated the effects of 28-day oral ZnO NP exposure on hepatic function, oxidative stress, apoptosis, inflammatory signaling, and microRNA expression in rats. Sixty male Wistar albino rats were allocated to three groups (

Indexed as

ApoptosisChemical and Drug Induced Liver InjuryLiverMicroRNAsNanoparticlesOxidative StressZinc OxideAnimalsDose-Response Relationship, DrugGene Expression RegulationGlutathioneMaleMalondialdehydeRatsRats, WistarGlutathioneMalondialdehydeMicroRNAsMIRN122 microRNA, ratmirn21 microRNA, ratMIRN34 microRNA, ratZinc Oxideapoptosishepatotoxicityinflammatory signalingmicroRNAsoxidative stresszinc oxide nanoparticles

Identifiers

PMID42794503
PMCPMC13606849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.