Evidence map›Paper›PMID 42794462›Full record

ArticleInternational journal of molecular sciences2026

Ribitoborate Synergism with Histone Deacetylase Inhibitor Romidepsin as a Potential Treatment for Breast Cancer.

Ravi Doddapaneni, Jason D Tucker, Jian Zhang, Pei J Lu, Qi L Lu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ravi DoddapaneniMcColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Wake Forest University School of Medicine, Charlotte, NC 28203, USA.
Jason D TuckerMcColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Wake Forest University School of Medicine, Charlotte, NC 28203, USA.ORCID 0000-0001-6558-7808
Jian ZhangFitzsimons Bioscience Park Center, Z Biotech, LLC, Aurora, CO 80045, USA.ORCID 0009-0005-2867-2620
Pei J LuMcColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Wake Forest University School of Medicine, Charlotte, NC 28203, USA.
Qi L LuMcColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Wake Forest University School of Medicine, Charlotte, NC 28203, USA.

Funding

Atrium Health Foundation 5713
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is a subtype associated with poor prognosis and low survival rates, largely due to limited treatment options. In recent years, histone deacetylase (HDAC) inhibitors have emerged as promising anti-cancer candidates due to their attractive epigenetic properties and distinct mechanisms of action but have shown limited success in solid tumors. Here, we explore ribitoborate along with HDAC inhibitors for potential use as a treatment for TNBC. Experiments were performed on the TNBC cell line MDA-MB-231. The results of the study revealed that ribitoborate and romidepsin showed synergistic responses leading to significant arrest of cell proliferation (80%) (

Indexed as

DepsipeptidesHistone Deacetylase InhibitorsTriple Negative Breast NeoplasmsApoptosisCell Line, TumorCell MovementCell ProliferationDrug SynergismFemaleGene Expression Regulation, NeoplasticHumansMDA-MB-231 CellsDepsipeptidesHistone Deacetylase Inhibitorsromidepsinhistone deacetylase inhibitorsribitoborateromidepsintriple-negative breast cancer

Identifiers

PMID42794462
PMCPMC13606832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.