Evidence map›Paper›PMID 42794443›Full record

ArticleInternational journal of molecular sciences2026

Nerve Cell Responses to Biocompatible RGO-Chitosan-CMC Nanofiber Composite Membranes.

Quentin Sins, Giulia Zo, Giuliana Paravizzini, Elena Raluca Sandu, Stefania Raimondo, Wang Meng-Jiy, Federica Fregnan, Yuki Shirosaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Quentin SinsDepartment of Engineering, Graduate School of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi 804-8550, Fukuoka, Japan.
Giulia ZoDepartment of Clinical and Biological Sciences, and Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
Giuliana ParavizziniDepartment of Clinical and Biological Sciences, and Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.ORCID 0009-0000-3341-5489
Elena Raluca SanduDepartment of Clinical and Biological Sciences, and Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
Stefania RaimondoDepartment of Clinical and Biological Sciences, and Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.ORCID 0000-0002-8907-473X
Wang Meng-JiyDepartment of Chemical Engineering, National Taiwan University of Science and Technology, No. 43, Sec. 4, Keelung Rd., Taipei 106, Taiwan.
Federica FregnanDepartment of Clinical and Biological Sciences, and Cavalieri Ottolenghi Neuroscience Institute, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
Yuki ShirosakiDepartment of Materials Science, Faculty of Engineering, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu-shi 804-8550, Fukuoka, Japan.ORCID 0000-0003-4207-4393

Funding

Heiwa Nakajima FoundationKyushu Institute of Technology Kyutech-NTUST-2023-03
6 · The paper itself

Abstract

Peripheral nerve injuries are common traumas that are difficult to overcome. Although nerve grafting can quickly recover nearly all sensitivity and function, graft availability remains an issue. Research has focused on ways to directly rebuild and promote the healing of damaged nerves using surgically implanted scaffolds. Nerve regeneration can be further promoted through strategies aimed at enhancing the regenerative microenvironment, such as improving the electrical conductivity of nerve guidance conduits. In this study, composite films of chitosan (Ch) and carboxymethyl cellulose (CMC) nanofibers were prepared. To improve the films' conductivity, reduced graphene oxide (RGO) was added. Structural analysis indicated interactions between Ch and CMC and showed that incorporation of RGO did not produce additional detectable crystalline phases. ChCMCRGO films showed slightly higher conductivity and greater surface hydrophilicity than ChCMC membranes and supported greater neurite outgrowth.

Indexed as

Biocompatible MaterialsCarboxymethylcellulose SodiumChitosanGraphiteNanofibersNeuronsAnimalsCell ProliferationElectric ConductivityMembranes, ArtificialNerve RegenerationRatsTissue ScaffoldsBiocompatible MaterialsCarboxymethylcellulose SodiumChitosangraphene oxideGraphiteMembranes, Artificialcarboxymethylcellulosecell morphologycell proliferationchitosanelectroconductivityfilmnanofibernerve cell

Identifiers

PMID42794443
PMCPMC13606567

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.