Evidence map›Paper›PMID 42794425›Full record

ArticleInternational journal of molecular sciences2026

Generation and Characterization of the Human Anti-HTNV Antibody KJJ4.

Ziyan Chen, Yanbo Wang, Yongli Hou, Liang Fang, Linfeng Cheng, Yusi Zhang, Chunmei Zhang, Yun Zhang, Ying Ma, Kang Tang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ziyan ChenDepartment of Immunology, The Fourth Military Medical University, Xi'an 710032, China.
Yanbo WangDepartment of Microbiology, The Fourth Military Medical University, Xi'an 710032, China.
Yongli HouDepartment of Immunology, The Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0002-3523-0418
Liang FangDepartment of Immunology, The Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0002-8718-6113
Linfeng ChengDepartment of Microbiology, The Fourth Military Medical University, Xi'an 710032, China.
Yusi ZhangDepartment of Immunology, The Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0003-4272-857X
Chunmei ZhangDepartment of Immunology, The Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0002-0882-9361
Yun ZhangDepartment of Immunology, The Fourth Military Medical University, Xi'an 710032, China.
Ying MaDepartment of Immunology, The Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0002-1936-3982
Kang TangDepartment of Immunology, The Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0002-6756-0219
Lihua ChenDepartment of Immunology, The Fourth Military Medical University, Xi'an 710032, China.

Funding

Key Project of the Natural Science Basic Research Program of Shaanxi Province 2025SYS-SYSZD-091National Natural Science Foundation of China 82071848the Key Research and Development Program of Shaanxi Province 2024SF-YBXM-286
6 · The paper itself

Abstract

Hantaan virus (HTNV) is the predominant causative agent of hemorrhagic fever with renal syndrome (HFRS) in China, yet no specific antiviral therapy is currently available. Neutralizing antibodies (NAbs) represent a promising strategy, but most existing anti-HTNV NAbs are heterologous and carry immunogenicity risks. Here, two fully human antibodies from a previously established human anti-HTNV phage display library were generated and characterized. KJJ3, a VL-VL tandem antibody derived from clone 3-12, showed weak binding to inactivated HTNV and minimal neutralizing activity (IC

Indexed as

Antibodies, NeutralizingAntibodies, ViralHantaan virusAnimalsChlorocebus aethiopsHemorrhagic Fever with Renal SyndromeHumansImmunoglobulin GNeutralization TestsVero CellsAntibodies, NeutralizingAntibodies, ViralImmunoglobulin Gglycoprotein GnHantaan virus (HTNV)IgG4in vitro neutralizationneutralizing antibodies (NAbs)

Identifiers

PMID42794425
PMCPMC13606443

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.