Evidence map›Paper›PMID 42794422›Full record

ArticleInternational journal of molecular sciences2026

TLR4: A Potential Therapeutic Target in the Experimental Pathogenesis of Hemolytic-Uremic Syndrome.

Elisa Varrone, Veronica Pepe, Gianluca Storci, Massimiliano Bonafè, Barbara Brunetti, Maurizio Brigotti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elisa VarroneDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.
Veronica PepeDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.
Gianluca StorciIRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Massimiliano BonafèDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-5218-6551
Barbara BrunettiDepartment of Veterinary Medical Sciences (DIMEVET), University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy.ORCID 0000-0002-2694-905X
Maurizio BrigottiDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.ORCID 0000-0001-7429-744X

Funding

Progetto ALICE ONLUS Associazione per la lotta alla SEU 2025University of Bologna RFO2025
6 · The paper itself

Abstract

Childhood infections by Shiga toxin (Stx)-producing

Indexed as

Hemolytic-Uremic SyndromeToll-Like Receptor 4AnimalsAntibodies, MonoclonalBlood PlateletsChlorocebus aethiopsExtracellular VesiclesHumansNeutrophilsShiga-Toxigenic Escherichia coliShiga Toxin 2Vero CellsAntibodies, MonoclonalShiga Toxin 2TLR4 protein, humanToll-Like Receptor 4extracellular vesicleshemolytic-uremic syndromeShiga toxinsToll-like receptor 4

Identifiers

PMID42794422
PMCPMC13607936

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.