Evidence map›Paper›PMID 42794419›Full record

ArticleInternational journal of molecular sciences2026

MORG1 Haploinsufficiency Is Associated with Stage- and Sex-Dependent Renoprotection and Signalling Alterations in Diabetic Kidney Disease.

Jonas Till Ihle, Luisa Duong, Nadja Ziller, Eric Jankowski, Karin Elflein, Alexander Berndt, Nikolaus Gaßler, Gunter Wolf, Ivonne Loeffler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jonas Till IhleDepartment of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany.
Luisa DuongDepartment of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany.
Nadja ZillerDepartment of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany.ORCID 0000-0003-1548-4741
Eric JankowskiDepartment of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany.
Karin ElfleinCentral Experimental Animal Facility, Jena University Hospital, 07747 Jena, Germany.
Alexander BerndtSection Pathology, Institute of Forensic Medicine, Jena University Hospital Jena, 07747 Jena, Germany.
Nikolaus GaßlerSection Pathology, Institute of Forensic Medicine, Jena University Hospital Jena, 07747 Jena, Germany.
Gunter WolfDepartment of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany.ORCID 0000-0002-3291-0610
Ivonne LoefflerDepartment of Internal Medicine III, Jena University Hospital, 07747 Jena, Germany.ORCID 0000-0003-4982-5647

Funding

Bundesministerium für Forschung, Technologie und RaumfahrtIZKF
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is a major age-associated metabolic disease, and aging substantially contributes to the increasing burden and progression of chronic complications, including diabetic kidney disease (DKD). However, the molecular mechanisms underlying changes in renal susceptibility during disease progression remain incompletely understood. We hypothesized that the scaffold protein mitogen-activated protein kinase organizer 1 (MORG1/WDR83) contributes to stage-dependent differences in DKD and that these effects may vary according to biological sex. Heterozygous

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesHaploinsufficiencyAlbuminuriaAnimalsFemaleFibrosisHypoxia-Inducible Factor 1, alpha SubunitKidneyMaleMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLSex FactorsSignal TransductionHypoxia-Inducible Factor 1, alpha SubunitMechanistic Target of Rapamycin Complex 1agingdiabetic kidney diseasedisease progressionsex differences

Identifiers

PMID42794419
PMCPMC13606655

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.