ArticleInternational journal of molecular sciences2026
Comparative Characterisation of Subcutaneous, Intraperitoneal and Intrabursal OVCAR3 Models.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
OVCAR3 cells are widely used to establish animal models of high-grade serous ovarian cancer (HGSOC) via subcutaneous (SC), intraperitoneal (IP), and intrabursal (IB) routes. However, direct comparisons of tumour development across these implantation routes are limited. This study compared the establishment, progression, dissemination and histological characteristics of SC, IP and IB OVCAR3 xenografts in female athymic nude mice over defined route-specific assessment periods. Tumour development was evaluated using semi-quantitative tumour scoring, histological assessment, nuclear morphometry and immunofluorescence staining for PAX8, WT1 and Ki67. IP and IB routes achieved 100% engraftment whereas SC implantation achieved engraftment in 15 of 18 animals. IP produced rapid carcinomatosis by Week 2, IB produced localised ovarian growth before contralateral spread, and SC produced confined stromal-encapsulated tumours. Mechanical confinement in the IB niche increased intratumoural density (1087 cells/mm
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