ArticleGels (Basel, Switzerland)2026
Enzyme-Instructed Self-Assembling Peptide Hydrogels for Sustained Subconjunctival Delivery of Dexamethasone: A Stereochemical Comparison of L- and D-Enantiomeric Peptides for Postoperative Ocular Anti-Inflammatory Therapy.
Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sustained postoperative anti-inflammatory therapy following intraocular surgery remains an unmet clinical need, as conventional topical corticosteroid eye drops suffer from poor bioavailability, patient non-compliance, and an inability to maintain therapeutic drug levels over the multi-week inflammatory resolution period. Here we report the development and characterization of alkaline phosphatase (ALP)-responsive enzyme-instructed self-assembling (EISA) peptide hydrogels based on the ultrashort amphiphilic sequence NapFFKY(p)-OH, covalently conjugated with dexamethasone (DEX) via an ester-cleavable succinyl linker, in both L- and D-enantiomeric forms, as injectable platforms for subconjunctival drug delivery. Both conjugates, L-NapFFK(DEX)Y(p)-OH and D-NapFFK(DEX)Y(p)-OH, were synthesized with chemical purity (87.3% and 89.8%, respectively) and theoretical DEX loading of 29.58%
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