ArticleGels (Basel, Switzerland)2026
pH-Responsive Mixed Polymeric Micelles as Gel-Related Nanocarriers for Drug Delivery: A DPD Study on Block Ratio Modulation.
Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Polymeric micelles represent a fundamental self-assembled architecture of gel-based soft materials and have emerged as promising nanocarriers for anticancer drug delivery. Their performance is largely governed by the block composition of constituent copolymers, and understanding their self-assembly behavior provides critical insights into the rational design of gel-related drug delivery systems. In this work, dissipative particle dynamics (DPD) simulations were performed to systematically investigate two types of mixed drug-loaded micellar systems self-assembled from a triblock copolymer mPEG-b-poly(2-(diethylamino)ethyl methacrylate)-b-PMMA (PDEAEMA, hereafter referred to as the DMA block for brevity) with either a diblock copolymer PDEAEMA-b-PMMA (polymer B) or PPEGMA-b-PDEAEMA (polymer C). By tailoring the ratios of hydrophobic (MMA, the constituent block of PMMA) and pH-sensitive (DMA) blocks, the protonation-responsive behavior, structural stability, drug loading capacity, and release kinetics of the micelles were comprehensively examined. The simulation results demonstrate that: (1) increasing the hydrophobic block ratio accelerates the protonation-triggered micellar swelling and drug release because the increased hydrophobic content enhances the core compactness which, upon protonation, generates a stronger driving force for chain extension, yet an optimal ratio (+16 MMA units) exists beyond which excessive hydrophobic blocks suppress release due to core densification; (2) increasing the pH-sensitive block ratio significantly enhances the maximum drug loading capacity (from 9.83% to 12.22% for the A/C system), but exerts only limited influence on the release rate; (3) the A/C mixed micelles with higher PEG content exhibit superior structural stability and drug loading capacity, while the A/B system with higher MMA content displays more sensitive pH-responsiveness. These findings reveal a competing mechanism between "protonation-driven force" and "structural resistance," providing mesoscopic theoretical guidance for the rational design of pH-responsive polymeric nanocarriers and self-assembled soft materials via block ratio modulation.
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