ArticleGels (Basel, Switzerland)2026
Study on Berberine/Glycyrrhizic Acid Monoammonium Salt Self-Assembled Hydrogel for Diabetic Wound Healing.
Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Diabetic chronic wounds face multiple intractable healing obstacles including sustained inflammation, severe infection, insufficient angiogenesis and defective collagen deposition. Current dressings fail to simultaneously relieve all these pathological defects. Herein, we constructed a carrier-free binary self-assembled Glycyrrhizic acid monoammonium salt-Berberine (GB) hydrogel composed of berberine and glycyrrhizic acid monoammonium salt, which forms interconnected nanofiber networks via one-pot thermally assisted small-molecule co-assembly without chemical crosslinking or exogenous polymer carriers. Relying on intermolecular non-covalent interactions, this single supramolecular material integrates anti-inflammatory, broad-spectrum antibacterial, pro-angiogenic, and collagen-regenerative multifunctions, which simultaneously ameliorates multiple core pathological obstacles of diabetic wounds within one formulation. We systematically characterized its physicochemical features, biocompatibility, and antibacterial and anti-inflammatory activities, as well as in vivo wound repair performance. This hydrogel formed uniform nanofibrous architectures with favorable viscoelastic properties and pH-dependent sustained release. In vitro assays verified its outstanding biosafety, broad-spectrum bacteriostasis against
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