ReviewGels (Basel, Switzerland)2026
Bridging Scales: Integrating Hyaluronan-Based Nanoencapsulation into 3D Hydrogel Constructs for Advanced Therapeutics-A Comprehensive Review.
Review in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The integration of nanoscale drug carriers within macroscale three-dimensional (3D) hydrogel architectures represents a paradigm shift in biomaterials design, enabling hierarchical control over therapeutic delivery. Hyaluronan (hyaluronic acid, HA), a native glycosaminoglycan of the extracellular matrix (ECM), has emerged as an exceptionally versatile building block for both nanoscale encapsulation systems and macroscale hydrogel scaffolds. This comprehensive review examines the rationale, fabrication strategies, and therapeutic applications of hyaluronan-based nanoencapsulation integrated within 3D hydrogel constructs, highlighting how this multiscale approach bridges the gap between molecular drug stabilization and tissue-level regenerative outcomes. We explore the chemical versatility of HA, the design principles of nanoencapsulation systems, the synthesis of 3D HA hydrogels, and the strategies for integrating these systems into unified therapeutic platforms. Applications in 3D bioprinting, injectable hydrogels, organ-on-a-chip models, cancer therapy, and tissue regeneration are critically evaluated. Finally, we discuss translational challenges, regulatory considerations, and future perspectives for clinical implementation of these advanced therapeutic systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.