Injectable Hydroxyapatite-Reinforced Methacrylated Recombinant Type III Collagen Microgels for Soft-Tissue Filling.

Qianqian Zhu, Cuicui Wu, Xi Luo, Shihao Dong, Beijuan Luo, Changcheng Yin, Zhuangzhuang Cai, Shunqing Tang

Abstract read

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Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Qianqian ZhuKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.ORCID 0009-0002-7730-7521

Cuicui WuKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.ORCID 0009-0002-0686-286X

Xi LuoKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Shihao DongKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Beijuan LuoKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Changcheng YinKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Zhuangzhuang CaiKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Shunqing TangKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.

Funding

Guangdong Basic and Applied Basic Research Foundation 2022A1515110181he Chinese Fundamental Research Funds for the Central Universities 21620339National Natural Science Foundation of China 32171312Production, teaching and Research Foundation of Ministry of Education 2023GY053the Key Areas Research and Development Program of Guangzhou 202103030003the Key Areas Research and Development Program of Guangzhou 2023B03J1241

6 · The paper itself

Abstract

Injectable fillers that combine immediate volume restoration with a sustained biological response remain of considerable interest in minimally invasive aesthetic medicine. In this study, a hydroxyapatite-loaded methacrylated recombinant type III collagen microgel (HAp@rhCol III-MA) was prepared by in situ coprecipitation and photocrosslinking. Recombinant type III collagen (rhCol III) was functionalized with methacryloyl groups to obtain rhCol III-MA, after which a calcium phosphate phase was mineralized in the presence of the modified collagen and the collagen phase was crosslinked under ultraviolet irradiation. More than 80% of the microgel particles prepared at 900 rpm were 20-80 μm in diameter. Spectroscopic, elemental, thermal, and diffraction analyses supported the incorporation of a poorly crystalline, HAp-compatible calcium phosphate phase, while rheological measurements showed higher storage and loss moduli than those of rhCol III-MA gel. HAp@rhCol III-MA did not reduce NIH-3T3 cell viability at the tested concentrations and enhanced HUVEC scratch closure and tube-network formation in vitro. Following subcutaneous implantation in rats, the microgel retained more volume than rhCol III-MA during the early and intermediate observation periods, with residual volumes of 56.58 ± 3.03 mm

Indexed as

dermal fillinghydroxyapatitemethacryloylationmicrogelrecombinant type III collagen

Identifiers

PMID42794312

DOI10.3390/gels12090762

PMCPMC13606857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.