ArticleGels (Basel, Switzerland)2026
Formulation and Release Kinetics of Neomycin Sulfate from a Polymeric Oil-in-Water Emulgel for Topical Application: A Proof-of-Concept Study.
Article in Gels (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This proof-of-concept study aimed to develop and characterize a polymeric oil-in-water emulgel containing neomycin sulfate for topical application, using chitosan and methylcellulose as gelling agents, Tween 80 as emulsifier, and sweet almond oil as the oily phase. The novelty of the study lies in the formulation of a chitosan-methylcellulose oil-in-water emulgel for a highly hydrophilic aminoglycoside antibiotic, together with the integrated evaluation of its microstructure, rheological behavior, hydration capacity, and release kinetics. The formulation was evaluated in terms of physicochemical properties, microstructure, rheological behavior, short-term stability, drug content, and in vitro release performance. Rheological analysis showed pseudoplastic behavior, with apparent viscosity decreasing as the rotational speed increased, indicating suitable spreadability under applied stress. The neomycin sulfate content was 99.1 ± 0.7%, demonstrating efficient incorporation of the active substance. In vitro release testing showed a progressive release profile, reaching 70.1% of the theoretical drug content after 120 min. Kinetic analysis showed that the zero-order model gave the best empirical fit over the interval studied (R
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