ArticleChildren (Basel, Switzerland)2026
Retinal Vascular Caliber and Its Ocular and Systemic Correlates in Children Living at High Altitude.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesThe retina is a highly metabolically active tissue that depends on precise vascular regulation. Childhood represents a critical period of ocular growth, and retinal vascular characteristics may provide insights into the relationship between microvascular development, ocular biometry, and refractive development. However, retinal vascular parameters in children living at high altitude remain poorly characterized. Our goal was to characterize retinal vascular caliber and evaluate its associations with ocular biometric parameters, refractive status, and peripheral oxygen saturation among children living at high altitude.
methodsThis cross-sectional baseline analysis included 1410 children from the Lhasa Childhood Eye Study. Retinal vascular parameters, including central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), and arteriolar-to-venular ratio (AVR), were measured from fundus photographs using computer-assisted IVAN software. Ocular biometric parameters, cycloplegic refraction, and SpO
resultsThe mean age was 7.90 ± 0.49 years, and 47.6% were female. Girls had shorter axial length (AL) and larger CRAE and CRVE than boys. Longer AL was associated with smaller CRAE (B = -5.64,
conclusionsRetinal vascular caliber was associated with ocular biometric characteristics, SpO
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