ArticleChildren (Basel, Switzerland)2026
Echocardiographic Evaluation of Systolic and Diastolic Cardiac Functions in Pediatric Cirrhosis: Unmasking Subclinical Alterations and Correlation with Liver Severity Scores.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis prospective study evaluated systolic and diastolic cardiac functions in pediatric cirrhosis using conventional and tissue Doppler imaging (TDI), and explored their correlation with liver severity scores.
methodsConducted at Inonu University, we enrolled 75 pediatric cirrhotic patients (44 compensated, 31 decompensated) from Pediatric Gastroenterology and 61 controls of similar age and sex without structural/functional heart disease from Pediatric Cardiology outpatients. All underwent clinical, laboratory, and echocardiographic assessments. To address multiple testing, Bonferroni correction was applied. Adjustments for age, sex, and disease severity were integrated into the correlation matrices to control for confounding parameters.
resultsThe cirrhosis cohort exhibited significantly higher heart rates, ejection fractions, and aortic/pulmonary velocity-time integrals than controls (
conclusionsHyperdynamic circulation appears to mask resting systolic metrics in pediatric cirrhosis. However, prolonged diastolic phases and increased MPI suggest presence of subclinical myocardial dysfunction, especially during clinical decompensation. Routine non-invasive liver staging scores show potential clinical utility as ancillary screening tools for early cardiovascular risk evaluation.
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