Evidence map›Paper›PMID 42794156›Full record

ArticleChildren (Basel, Switzerland)2026

The Longitudinal Physiological Reference Values of Middle Cerebral Artery Blood Flow Velocity in Extremely Preterm Infants: A Study Utilizing Multimodal Cerebral Hemodynamic Monitors.

Wei-Hung Wu, Yu-Tang Juan, Shu-Yu Lin, Ming-Chou Chiang, Mei-Yin Lai, I-Hsyuan Wu, Shih-Ming Chu, Reyin Lien, Kai-Hsiang Hsu

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Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Wei-Hung WuDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan 33305, Taiwan.
Yu-Tang JuanDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan 33305, Taiwan.
Shu-Yu LinDepartment of Pediatrics, Chang Gung Memorial Hospital Taipei Branch, Taipei 10507, Taiwan.ORCID 0009-0008-8626-0933
Ming-Chou ChiangDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan 33305, Taiwan.ORCID 0000-0003-1109-0665
Mei-Yin LaiDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan 33305, Taiwan.
I-Hsyuan WuDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan 33305, Taiwan.
Shih-Ming ChuDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan 33305, Taiwan.
Reyin LienDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan 33305, Taiwan.
Kai-Hsiang HsuDivision of Neonatology, Department of Pediatrics, Chang Gung Memorial Hospital Linkou Branch, Taoyuan 33305, Taiwan.ORCID 0000-0003-2852-6322

Funding

Linkou Chang Gung Memorial Hospital BMRPK60National Science and Technology Council 111-2314-B-182A-100-
6 · The paper itself

Abstract

backgroundCerebral blood flow (CBF) is essential for maintaining cerebral metabolism in extremely preterm infants; however, no universally accepted reference standard exists for CBF velocity (CBFV). This study aimed to establish physiological reference patterns of middle cerebral artery CBFV under strictly defined physiological stability using multimodal monitoring.

methodsThis post-hoc analysis included extremely preterm infants (gestational age ≤ 28

resultsForty infants contributed 194 normal CBFV datasets. Physiological reference ranges for peak systolic velocity (PSV), end-diastolic velocity (EDV), mean velocity (MV), resistance index (RI), and pulsatility index (PI) were established across PMA and concurrent weight strata. Both PSV and MV were associated with PMA and concurrent weight (

conclusionsPSV and MV were maturation-dependent cerebral perfusion markers. Multimodally defined physiological stability provides a robust framework for establishing clinically relevant reference values for middle cerebral artery CBFV in extremely preterm infants.

Indexed as

cerebral blood flowcerebral hemodynamicsDoppler ultrasonographyextremely preterm infantsnear-infrared spectroscopy (NIRS)

Identifiers

PMID42794156
PMCPMC13605464

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.