ArticleChildren (Basel, Switzerland)2026
Exploratory Hemodynamic and Hematologic Trajectories by Culture Status Among Neonates Evaluated for Infection.
Article in Children (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNeonates evaluated for infection undergo rapid physiologic transition, making isolated measurements difficult to interpret. Because a positive culture field does not by itself establish clinical sepsis, we explored whether physiologic and laboratory trajectories differed by recorded culture status during the first three postnatal days.
methodsThis single-center prospective observational longitudinal study included 65 neonates with linked measurements on days 1, 2, and 3. The exposure was a binary culture field in the source database; specimen source, organism identity, and pathogen-versus-contaminant adjudication were unavailable. Group-specific medians were summarized, and gestational-age-adjusted linear models with patient-clustered robust standard errors tested culture status, time, and culture-status-by-time effects.
resultsThe cohort included 26 culture-positive and 39 culture-negative neonates. On day 1, the culture-positive group had lower median systolic blood pressure (48.5 vs. 57.0 mmHg), diastolic blood pressure (24.5 vs. 33.0 mmHg), and MAP (31.0 vs. 41.0 mmHg), more negative base excess (-7.65 vs. -3.60 mmol/L), and lower platelet counts (219 vs. 282 × 10
conclusionsRecorded culture status was associated with selected early hemodynamic, metabolic, and hematologic differences in this small exploratory cohort. These associations cannot be considered sepsis-specific and require confirmation after clinical culture adjudication, standardized timestamping and blood-pressure measurement, inclusion of fatal cases, and adjustment for illness severity and treatment exposures.
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