ArticleFoods (Basel, Switzerland)2026
Urinary Hypaphorine as a Candidate Marker of FFQ-Derived Legume Intake Within the EAT-Lancet Framework in Free-Living Adults.
Teresa Cepeda-Vidal, João Tomé-Carneiro, Alberto Valdés, Nieves Rocío Colás-Ruiz, Edwin Fernández-Cruz, Isabel Espinosa-Salinas, Pilar Matía-Martín, Ana Barabash-Bustelo, Angélica Larrad-Sainz, Miguel Ángel Rubio-Herrera and 3 more
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In one paragraphArticle in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Teresa Cepeda-VidalLaboratorio de Higiene, Inspección y Control de Alimentos (LHICA), Departamento de Química Analítica, Nutrición y Bromatología, Universidad de Santiago de Compostela, 15705 Santiago de Compostela, Spain.
João Tomé-CarneiroFood Bioactive Ingredients, Instituto Madrileño de Estudios Avanzados (IMDEA) Nutrition, Carretera de Cantoblanco 8, 28049 Madrid, Spain.ORCID 0000-0002-3597-9234 Alberto ValdésMetabolomics Platform, Institute of Food Science Research (CIAL, CSIC-UAM), Calle Nicolás Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0002-7901-5816 Nieves Rocío Colás-RuizMetabolomics Platform, Institute of Food Science Research (CIAL, CSIC-UAM), Calle Nicolás Cabrera 9, 28049 Madrid, Spain.ORCID 0000-0002-4031-6590 Isabel Espinosa-SalinasGENYAL Platform, Instituto Madrileño de Estudios Avanzados (IMDEA) Nutrition, Carretera de Cantoblanco 8, 28049 Madrid, Spain.ORCID 0000-0002-9526-891X Pilar Matía-MartínEndocrinology and Nutrition Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), 28040 Madrid, Spain.ORCID 0000-0001-9844-3755 Ana Barabash-BusteloEndocrinology and Nutrition Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), 28040 Madrid, Spain.ORCID 0000-0003-2383-1563 Angélica Larrad-SainzEndocrinology and Nutrition Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), 28040 Madrid, Spain.ORCID 0000-0001-7331-7672 Miguel Ángel Rubio-HerreraEndocrinology and Nutrition Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), 28040 Madrid, Spain.ORCID 0000-0002-0495-6240 Alfonso Luis Calle-PascualEndocrinology and Nutrition Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (IdISSC), 28040 Madrid, Spain.ORCID 0000-0002-3628-9323 Alberto Cepeda-SáezLaboratorio de Higiene, Inspección y Control de Alimentos (LHICA), Departamento de Química Analítica, Nutrición y Bromatología, Universidad de Santiago de Compostela, 15705 Santiago de Compostela, Spain.ORCID 0000-0002-9324-1342 J Alfredo MartínezCardiometabolic Precision Nutrition Program, Instituto Madrileño de Estudios Avanzados (IMDEA) Nutrition, Carretera de Cantoblanco 8, 28049 Madrid, Spain.
Funding
Institute of Health Carlos III AC21/00038
6 · The paper itselfAbstract
Dietary assessment is affected by recall, reporting, portion-size error, and food-composition inconsistencies. Hypaphorine, a tryptophan-derived betaine alkaloid found in pulses and other foods, has been proposed as a marker of legume exposure, but its performance in free-living populations remains uncertain. In this cross-sectional study of 138 adults, dietary intake was assessed by food-frequency questionnaire, and legume intake was represented by an FFQ-derived variable within the EAT-Lancet food-group framework. Urinary hypaphorine was quantified by targeted hydrophilic-interaction liquid chromatography-mass spectrometry. Associations were examined using Spearman correlations and multivariable linear models with HC3 robust standard errors. Predictive performance was assessed using repeated 10-fold cross-validation. Hypaphorine correlated with legume intake (
Indexed as
dietary intake biomarkerfood-frequency questionnairehypaphorinelegumesleukocytesnutritional epidemiologytargeted metabolomics
Identifiers
PMID42794064
PMCPMC13606740
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