ArticleEntropy (Basel, Switzerland)2026
Visibility-Graph Analysis of Raman Spectra in Chalazion and Lipid Dysregulation: An Exploratory Study.
Article in Entropy (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A chalazion is an inflammatory lesion of the eyelid caused by a blockage in the sebaceous glands. To identify subtle biochemical differences in chalazion secretions and patient serum, we apply a graph-theory-based visibility-graph approach to Raman spectra, focusing on its exploratory potential for detecting band-specific spectral differences. As a classical baseline, we also employ Principal Component Analysis (PCA); however, the visibility-graph approach provides complementary, band-localized information that may support interpretation of subtle spectral differences. The study included samples from chalazion patients and control subjects, comprising healthy individuals and patients with lipid disorders. Raman spectra were analyzed by transforming the data into visibility graphs, enabling identification of hidden correlations and signal dynamics. Within the VG representation, group differences were concentrated mainly in the 1100-1300 cm
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