Liposomal Honokiol Nanoparticles Attenuate Manganese-Induced Hippocampal Neurotoxicity via NRF2/HO-1 and SIRT1/PGC-1α Pathways: Association with Oxidative Stress, Neuroinflammation, Mitochondrial Dysfunction, and Apoptosis.

Raed Al Ruwaili, Ekramy M Elmorsy, Mohamed M Abdel-Daim, Eida M Alshammari, Aly A M Shaalan, Ola A Habotta, Manal S Fawzy, Mai Salem

Abstract read

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In one paragraph

Article in Brain sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raed Al RuwailiDepartment of Internal Medicine, College of Medicine, Northern Border University, Arar 91431, Saudi Arabia.

Ekramy M ElmorsyCenter for Health Research, Northern Border University, Arar 73213, Saudi Arabia.

Mohamed M Abdel-DaimDepartment of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, Jeddah 21442, Saudi Arabia.ORCID 0000-0002-4341-2713

Eida M AlshammariDepartment of Chemistry, College of Sciences, University of Ha'il, Ha'il 2440, Saudi Arabia.ORCID 0000-0003-2948-5040

Aly A M ShaalanDepartment of Anatomy, Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia.

Ola A HabottaDepartment of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0003-0067-2838

Manal S FawzyCenter for Health Research, Northern Border University, Arar 73213, Saudi Arabia.ORCID 0000-0003-1252-8403

Mai SalemDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.ORCID 0000-0002-2425-5994

Funding

Northern Border University NBU-CRP-2026-1442

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

honokiolliposomal nanoformulationmanganese mining neurotoxicityneuroinflammationNRF2/SIRT1 signalingoxidative stress

Identifiers

PMID42793325

DOI10.3390/brainsci16090900

PMCPMC13604269

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.