Evidence map›Paper›PMID 42793278›Full record

ArticleCurrent issues in molecular biology2026

Cross-Species Triage of SERT-Oriented Polyheteroaryl Candidates Prioritizes AD20/UtIA-0108 as an Early Neuroactive Candidate.

Maria V Komelkova, Stanislav A Fedorov, Veronika A Isaeva, Irina A Utepova, Yulia D Grygoreva, Inessa Yu Bahareva, Vitalii S Moskaliuk, Elena M Kondaurova, Alexandr V Zhdanov, Pavel O Platkovskii and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current issues in molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maria V KomelkovaRussian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia.ORCID 0000-0003-2431-8358
Stanislav A FedorovRussian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia.ORCID 0000-0002-9937-2677
Veronika A IsaevaLaboratory of Immunopathophysiology, Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences, 106 Pervomaiskaya Street, 620049 Ekaterinburg, Russia.
Irina A UtepovaRussian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia.ORCID 0000-0003-4692-9176
Yulia D GrygorevaFederal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Prospekt Akademika Lavrent'yeva, 630090 Novosibirsk, Russia.
Inessa Yu BaharevaFederal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Prospekt Akademika Lavrent'yeva, 630090 Novosibirsk, Russia.
Vitalii S MoskaliukFederal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Prospekt Akademika Lavrent'yeva, 630090 Novosibirsk, Russia.
Elena M KondaurovaFederal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Prospekt Akademika Lavrent'yeva, 630090 Novosibirsk, Russia.
Alexandr V ZhdanovRussian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia.ORCID 0000-0003-4004-8976
Pavel O PlatkovskiiRussian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia.
Maria A TrestsovaRussian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia.
Daria A AndreevaDepartment of Organic and Biomolecular Chemistry, Ural Federal University, 28 Mira Street, 620002 Ekaterinburg, Russia.
Maxim A PerfilevScientific Center for Innovative Medicines, Volgograd State Medical University, 1 Pavshikh Bortsov Sq., 400066 Volgograd, Russia.ORCID 0000-0002-5326-3299
Andrey N KochetkovScientific Center for Innovative Medicines, Volgograd State Medical University, 1 Pavshikh Bortsov Sq., 400066 Volgograd, Russia.
Pavel M VassilievRussian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia.ORCID 0000-0002-8188-5052
Vladimir S NaumenkoFederal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 10 Prospekt Akademika Lavrent'yeva, 630090 Novosibirsk, Russia.ORCID 0000-0001-7196-4729
Alexey P SarapultsevRussian-Chinese Education and Research Center of System Pathology, South Ural State University, 76 Lenin Prospekt, 454080 Chelyabinsk, Russia.ORCID 0000-0003-3101-9655

Funding

RSF 25-13-20056
6 · The paper itself

Abstract

Depression and stress-related disorders remain important targets for the development of new neuroactive compounds. We evaluated three imidazo[1,2-a]pyridine-[1,2,5]oxadiazolo[3,4-b]pyrazine derivatives, selected by a SERT-oriented computational screen, using chemical characterization, zebrafish embryo toxicity, larval and adult zebrafish behavioural assays, mouse behavioural HPLC, and qPCR experiments. AD19/UtIA-0167 had the highest computational consensus but showed greater embryo toxicity and no consistent advantage in adult zebrafish. AD20/UtIA-0108 showed a distinct larval locomotor profile, increased middle-zone occupancy after chronic exposure in stressed adult zebrafish, and was therefore examined in mice. Chronic AD20 increased latency to enter the dark compartment; whereas, time in the light compartment, open-field measures and forced-swim immobility were unchanged. HPLC and qPCR changes were region-specific and did not demonstrate direct SERT engagement. AD20 should therefore be regarded as an early neuroactive candidate from a SERT-oriented screen, not as a confirmed SERT inhibitor or antidepressant. Interpretation across species is limited by the duplicated zebrafish serotonin-transporter system, waterborne exposure and the limited scope of the mouse behavioural effect. Direct transporter assays, pharmacokinetic studies and independent behavioural replication are required.

Indexed as

AD20/UtIA-0108chronic unpredictable stressdrug discoveryimidazo[1,2-a]pyridinelight–dark testmolecular dockingmonoaminergic multitarget candidateoxadiazolopyrazineSERT-oriented screeningzebrafish

Identifiers

PMID42793278
PMCPMC13605482

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.